BACKGROUND MicroRNAs (miRNAs) are a class of small non-coding RNAs that have recently emerged as important regulators of gene expression. They negatively regulate gene expression post-transcriptionally by translational repression and target mRNA degradation. miRNAs have been shown to play crucial roles in muscle development and in regulation of muscle cell proliferation and differentiation. M...

With many live imaging techniques, it is crucial that a deep level of anesthesia is reached and maintained throughout image acquisition without reducing zebrafish viability. This is particularly true for three-dimensional tomographic imaging modalities. Currently, the most commonly used anesthetic in the zebrafish community, MS-222 (tricaine methanesulfonate), does not allow this. We show, usin...

Anesthetics are often used to immobilise fishes in research. Many chemicals have been tested in anesthetisation of fishes and each chemical has its own merits and demerits. In the present study, four anesthetics namely, 2-phenoxyethanol, quinaldine, MS-222, and benzocaine were selected to test the efficiency in anesthetisation of common carp Cyprinus carpia. Results indicated that the induction...

Regenerative processes enhance postsynaptic potential (PSP) amplitude and behaviorally relevant temporal filtering in more than one-third of electrosensory neurons in the torus semicircularis of Eigenmannia. Data from in vivo current-clamp intracellular recordings indicate that these "regenerative PSPs" can be divided in two groups based on their half-amplitude durations: constant duration (CD)...

Inductive neural telemetry was used to record from microwire electrodes chronically implanted into the anterior lateral line nerve of the toadfish, Opsanus tau. Spontaneous neural activity and the response of lateral line fibers to water current were continually monitored from 17 primary afferent fibers before, during, and after the administration of the anesthetic tricaine (MS-222). Significan...

The radon-222 content of the ground-level air depends on source areas masses and local meteorological conditions.

Several cellular microRNAs show substantial changes in expression during HIV-1 infection and their active role in the viral life cycle is progressively emerging. In the present study, we found that HIV-1 infection of Jurkat T cells significantly induces the expression of miR-222. We show that this induction depends on HIV-1 Tat protein, which is able to increase the transcriptional activity of ...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Grzywna E, Kwiecień J. From the hypertransaminasemia symptoms to recognition of late-onset Pompe disease in a 12-year-old boy. Pediatria Polska - Polish Journal Paediatrics. 2021;96(3):220-222. doi:10.5114/polp.2021.109310. APA Grzywna, E., & Kwiecień, (2021). Paediatrics, 96(3), 220-222. https://doi.org/10.5114...

Anesthetics are drugs that reversibly relieve pain, decrease body movements and suppress neuronal activity. Most drugs only cover one of these effects; for instance, analgesics relieve pain but fail to block primary fiber responses to noxious stimuli. Alternately, paralytic drugs block synaptic transmission at neuromuscular junctions, thereby effectively paralyzing skeletal muscles. Thus, both ...