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Those who solve more of a given type of problem tend to get better at it which suggests that problems of any given type should be brought to specialists for a solution. However, in this paper we argue that agency-related costs and information transfer costs will tend to drive the locus of problem-solving in the opposite direction away from problem-solving by specialist suppliers, and towards th...
OBJECTIVE In vitro, transglutaminase-2 (TG2)-mediated activation of the β-catenin signaling pathway is central in warfarin-induced calcification, warranting inquiry into the importance of this signaling axis as a target for preventive therapy of vascular calcification in vivo. METHODS AND RESULTS The adverse effects of warfarin-induced elastocalcinosis in a rat model include calcification of ...
Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic (Bifidobacterium animalis subsp. lactis Bi-07, 109 colony-forming units (CFU)/d) or synbiotic (8 g XOS+109 CFU Bi-...
The hippocampus is an important brain region that is involved in neurological disorders such as Alzheimer disease, schizophrenia, and epilepsy. Ionotropic glutamate receptors-namely,N-methyl-D-aspartate (NMDA) receptors (NMDARs), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs), and kainic acid (KA) receptors (KARs)-are well known to be involved in these diseases by me...
*Corresponding author: Dr. Sanmati Kumar Jain, Associate Professor, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (Central University) Bilaspur, 495 009, Chhattisgarh, India. Tel: +91-7752-260027 E-mail: [email protected] Foundation Project: This work was financially supported by University Grant Commission (UGC), New Delhi, India [grant No. 10-01/2005 (SA-I)].
a North Carolina State University, Department of Chemical and Biomolecular Engineering, 911 Partners Way, Engineering Building 1, Rm 2-009, Raleigh NC 27695-7905, United States b Soft Condensed Matter, Debye Institute for Nanomaterials Science, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands c Unilever R&D Vlaardingen, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The N...
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