Because the control of HIV-1 replication is largely dependent on CD8+ T lymphocyte responses specific for immunodominant viral epitopes, vaccine strategies that increase the breadth of dominant epitope-specific responses should contribute to containing HIV-1 spread. Developing strategies to elicit such broad immune responses will require an understanding of the mechanisms responsible for focusi...

Background: Juvenile idiopathic arthritis (JIA) is a complex trait, the most common rheumatic disease in children. Considering clinical heterogeneity of disease, genetic background particular JIA subtypes may also vary significantly. Objectives: This work was aimed to reveal characteristic patterns HLA associations within 11 loci for two clinically different forms Belarusian population. Methods...

Leptin plays a key role in the regulation of the energy balance in mammals. Thus, the leptin and leptin receptor are being intensively studied in these animals. However, it remains unclear whether the leptin-mediated control mechanism is conserved in nonmammalian vertebrates such as the avian. In this study, the association of the SNP LEPR A286G with carcass traits was investigated in the EMBRA...

We previously discovered one particular HLA-A*02:01 mutant that enhanced peptide-specific cytotoxic T lymphocyte (CTL) recognition in vitro compared to wild-type HLA-A*02:01. This mutant contains a single amino acid substitution from histidine to leucine at position 74 (H74L) that is located in the peptide-binding groove. To investigate the effect of the H74L mutation on the in vivo CTL priming...

Recently a newly identified clinical syndrome of disseminated non-tuberculous mycobacterial diseases (with or without other opportunistic infections in adult patients who were previously healthy, has been recognized in association with an acquired autoantibody to interferon-gamma. This syndrome is emerging as an important cause of morbidity and mortality, especially among people of Asian descen...

The contribution of specific HLA Class II alleles in type 1 diabetes is determined by polymorphic amino acid epitopes that direct antigen binding therefore, along with conventional allele frequency analysis, epitope analysis can provide important insights into disease susceptibility. We analyzed the highly heterogeneous Cypriot population for the HLA class II loci of T1DM patients and controls ...

MSC: primary 01A70, 54H05 secondary 01-02, 26A21