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Strain Hhs.015(T) (Saccharothrix yanglingensis sp. nov.), an antagonistic endophytic Saccharothrix actinomycete isolated from roots of cucumber plants, exhibited a broad antimicrobial spectrum in vitro and was active as a biocontrol against plant diseases in field trials. The SSY medium was used for production of antimicrobial metabolites by strain Hhs.015(T). However, this medium is too expens...
PURPOSE ONYX-015 is a chimeric, E1B-deleted adenovirus designed to replicate preferentially in p53-deficient tumor cells; however, little is understood about its actual replication potential in human tumors. We hypothesized that replication of a late viral gene, hexon, would demonstrate replication of virus in human tissues. EXPERIMENTAL DESIGN In the course of a clinical trial, a patient wit...
Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway?
Increased knowledge of how normal cell growth is altered during tumorigenesis has led to the development of novel approaches to killing cancer cells. However, the application of novel tumor therapies, like conventional therapies, still depends on there being an effective means of selectively targeting tumors. One new approach uses an attenuated adenovirus (Ad) that has been designated ONYX-015 ...
Yan Li, David M.J. Tax, Robbert P.W. Duin and Marco Loog Pattern Recognition Laboratory, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands Tel: 015-2788 433, Email: [email protected]
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