Laminins are crucial for formation and function of basement membranes. We identified laminin β4 (LAMB4) as a structural component the dermal-epidermal junction autoantigen subepidermal autoimmune blistering disease anti-p200 pemphigoid using immunoprecipitation patient-derived antibodies extracts human skin followed by mass spectrometry. Epitope mapping revealed that all analyzed sera (20 20) r...

Psoriasis is a chronic inflammatory skin disease with strong Th17-skewed immune phenotype. It has been generally accepted that regulatory T cells in the lesional psoriasis have functional impairment. However, circulating Cutaneous Leukocyte Associated antigen(CLA)+ cell which potentially migrated out from not yet explored well so far especially Asians. Herein, to investigate whether CLA+regulat...

Details are given of the v ( S O ) ~ ~ ~ ~ stretching (dmso = dimethyl sulphoxide), v,(SO,), v,(SO,), and v,(SO,) regions of the Raman spectra of SO,-dmso mixtures at 293 K and sub-ambient temperatures. Analysis of the v( SO)dmso region, which contains at least seven component bands, provides evidence of several component species. Bands at 1 067,l 057, and 1 044 cm-l are due to monomers and ass...

From the Department of Transfusion Medicine, the Department of Clinical Immunology, and the Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital at Huddinge, Stockholm, Sweden. Address reprint requests to: Beatrice Diedrich, MD, Transfusion Medicine, C2 66, Karolinska University Hospital at Huddinge, 141 86 Stockholm, Sweden; e-mail: beatrice.diedrich@ karolinska.se. ...

We tested the hypothesis that the proportion of normal results in tests ordered by a physician correlates directly with the proportion of tests that are disapproved by a utilization review audit for inappropriate test use. Auditors reviewed 3497 charts for 13 067 repeated determinations of 10 diagnostic tests ordered by 81 medical residents to determine if test use had been appropriate, accordi...

Abstract. A re-evaluated data set of nitrogen dioxide (NO2) column densities over Rome for the years 1996 to 2017 is here presented. This long-term record obtained from ground-based direct sun measurements with a MkIV Brewer spectrophotometer (serial number #067) and further reprocessed using novel algorithm. Compared original algorithm, new method includes updated NO2 absorption cross sections...

Systemic inequalities still exist within Higher Education (HE). Reports from Universities UK show a 13% degree-awarding gap for Black, Asian and Minority Ethnic (BAME) students, with similar effects found when comparing students across other protected attributes, such as gender or disability. In this paper, we study whether existing prediction models to identify at risk of failing (and hence pr...

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