BACKGROUND & AIMS Severe alcoholic hepatitis (AH) has a poor short-term prognosis. Although infections are frequent complications of AH, the incidence of invasive aspergillosis (IA) and its impact on outcome remain unknown. METHODS We prospectively followed 94 biopsy-proven severe AH episodes for 3 months. We retrospectively reviewed our diagnosis of IA based on EORTC/MSG and AspICU criteria,...

OBJECTIVE The objective of this study was to find out the clinical variables correlated with repeated intra-arterial (IA) nimodipine infusions in patients with medically refractory cerebral vasospasm (CV) following subarachnoid hemorrhage (SAH). MATERIALS AND METHODS During the 36 months between January 2011 and December 2013, 275 patients were treated at our institute for SAH due to a ruptur...

BACKGROUND Circulating autoantibodies to pancreatic glutamic acid decarboxylase (GAD65; the 65-kDa isoform of glutamic acid decarboxylase), protein tyrosine phosphatase-like protein IA-2, and insulin can be used as predictive markers of type 1 diabetes. We developed a novel assay for the detection of IA-2 autoantibodies (IA-2As) in serum based on time-resolved fluorimetry, hypothesizing that th...

he risk of intracranial aneurysm (IA) is increased among individuals with first-degree relatives with history of IA. 1 Many approaches have been used to identify genes contributing to the risk of IA. 2–4 Genome-wide association studies identified and replicated associations on chromosome 4q31. Most studies utilized sporadic IA cases; familial cases may potentially involve different genetic risk...

We present extensive optical photometric and spectroscopic observations of the high-velocity (HV) Type Ia supernova (SN Ia) 2017fgc, covering phase from $\sim$ 12 d before to $\sim 389$ after maximum brightness. SN 2017fgc is similar normal SNe Ia, with an absolute peak magnitude $M_{\rm max}^{B} \approx$ $-19.32 \pm 0.13$ mag a post-peak decline ${\Delta}m_{15}(B)$ = $1.05 0.07$ mag. Its bolom...

David Hessel , Carolyn Lawrence , and Nick Lauter 1,2,3* 1 Interdepartmental Genetics Program, Iowa State University, Ames, IA, 50011, U.S.A. 2 Department of Plant Pathology, Iowa State University, Ames, IA, 50011, U.S.A 3 USDA-ARS Corn Insects and Crop Genetics Research, Ames, IA, 50011, U.S.A. 4 Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, 50011, U.S....

The identity of the progenitor systems of type-Ia supernovae (SNe Ia) is a major unsolved problem in astrophysics. SN Ia rates are providing some striking clues. We review the basics of SN rate measurement, preach about some sins of SN rate measurement and analysis, and illustrate one of these sins with an analogy about Martian scientists. We review the recent progress in measuring SN Ia rates ...

I discuss the use of Type Ia supernovae (SNe Ia) for cosmological distance determinations. Low-redshift SNe Ia (z < ∼ 0.1) demonstrate that the Hubble expansion is linear, that H0 = 72 ± 8 km s−1 Mpc−1, and that the properties of dust in other galaxies are similar to those of dust in the Milky Way. The light curves of high-redshift (z = 0.3–1) SNe Ia are stretched in a manner consistent with th...

I discuss the use of Type Ia supernovae (SNe Ia) for cosmological distance determinations. Low-redshift SNe Ia (z < ∼ 0.1) demonstrate that the Hubble expansion is linear with H0 = 72 ± 8 km s −1 Mpc, and that the properties of dust in other galaxies are generally similar to those of dust in the Milky Way. The light curves of high-redshift (z = 0.3– 1) SNe Ia are stretched in a manner consisten...

Type 1 diabetes (T1D) results from the destruction of pancreatic insulin-producing beta cells and is strongly associated with the presence of islet autoantibodies. Autoantibodies to tyrosine phosphatase-like protein IA-2 (IA-2As) are considered to be highly predictive markers of T1D. We developed a novel lateral flow immunoassay (LFIA) based on a bridging format for the rapid detection of IA-2A...