Background. Individuals with increased expression of components the IGF/INS system, are more likely to develop various malignancies. And in case when system overexpressed tumors, this adversely affects prognosis disease, including leading a decrease relapse-free survival. A characteristic feature is ability same ligands bind different receptors and vice versa (cross interactions) activate signa...

The insulin-like growth factors I and II (IGF-I and -II) are proteins which stimulate cell proliferation and are important in normal human growth and development. They are coded for by separate genes and bind to specific cell surface receptors, eliciting a mitogenic response. IGFs are secreted by several cell lines derived from adult tumors. We have examined a number of human adult tumors for I...

This study determined the effect of genetic variation, feed deprivation, and insulin-like growth factor-I (IGF-I) on weight loss, plasma IGF-I and growth hormone, and indexes of protein degradation in eight full-sibling families of rainbow trout. After 2 wk of feed deprivation, fish treated with IGF-I lost 16% less (P < 0.05) wet weight than untreated fish. Feed deprivation increased growth hor...

Teratocarcinoma is a germ-line carcinoma giving rise to an embryoid tumor with structures derived from the three embryonic layers: mesoderm, endoderm, and ectoderm. Teratocarcinoma is widely used as an in vitro model system to study regulation of cell determination and differentiation during mammalian embryogenesis. Murine embryonic carcinoma (EC) PCC3 cells express insulin-like growth factor I...

BACKGROUND: Airway remodeling in children with bronchial asthma is due to the effect of inflammatory mediators and growth factors on epithelium. Vitamin D (VitD) has immunomodulatory many diseases as asthma. The ant-inflammatory anti-fibrotic role VitD could prevent or improve air way asthmatic patients. AIM: study investigated supplementation expression transforming factor-beta (TGF-β), tumor ...

Abstract Acromegaly is a rare, chronic disease that is, in more than 95% of cases, caused by growth hormone (GH)-secreting pituitary adenoma. Overproduction insulin-like factor-1 (IGF-1) due to GH hypersecretion leads various clinical features characterized somatic overgrowth, physical changes, multiple comorbidities, and increased mortality. The average age at diagnosis 40 50 years, with no se...

Background & Objective: To find an association between gene variants of insulin-like growth factor-1 (IGF-1) and 5,10-methylenetetrahydrofolate reductase (MTHFR) with the risk of acne vulgaris (AV). Methods: In a case-control study, we investigated 150 AV patients and 148 healthy individuals (aged 18-25 years) for the IGF-1 G>A and MTHFR C677T polymorphis...

Sneddon, A. A., M. I. Delday, J. Steven, and C. A. Maltin. Elevated IGF-II mRNA and phosphorylation of 4EBP1 and p70S6k in muscle showing clenbuterol-induced anabolism. Am J Physiol Endocrinol Metab 281: E676–E682, 2001.—Muscle wasting affects large numbers of people, but few therapeutic approaches exist to treat and/or reverse this condition. The b2-adrenoceptor agonist clenbuterol produces a ...

The igf1 gene is alternatively spliced as IGF-IEa and IGF-IEc variants in humans. In fibrostenotic Crohn's disease, the fibrogenic cytokine TGF-β1 induces IGF-IEa expression and IGF-I production in intestinal smooth muscle and results in muscle hyperplasia and collagen I production that contribute to stricture formation. Mechano-growth factor (MGF) derived from IGF-IEc induces skeletal and card...