3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug that can cause severe and even fatal adverse effects. However, interest remains for its possible clinical applications in posttraumatic stress disorder and anxiety treatment. Preclinical studies to determine MDMA’s safety are needed. We evaluated MDMA’s pharmacokinetics and metabolism in male rats receiving 2.5, 5, and 10 ...

O R IG IN A L A R T IC L E INTRODUCTION Gastroesophageal refl ux disease (GERD) in infancy presents significantly greater incidence in the population with associated neurological disease. There is a consensus that multifactorial events are involved in its etiopathogenesis, which makes it diffi cult to evaluate the results from treatment and to obtain adequate uniformity regarding the most appro...

Sao Paulo Med J. 2007;125(6):333-7. O R IG IN A L A R T IC L E Mauro Karnikowski

O R IG IN A L A R T IC L E INTRODUCTION Adequate postoperative analgesia is considered to be a major key for reducing pul monary morbidity and improving the outcome. Thoracic epidural anesthesia (TEA) has been proposed as a reliable analgesic method following thoracic surgery. Most of these benefi ts, however, relate to the postoperative or to the so-called perioperative period. Some case repor...

Sao Paulo Med J. 2007;125(5):265-9. O R IG IN A L A R T IC L E Míriam Raquel Diniz Zanetti Rodrigo de Aquino Castro

The paper was conducted to understand the factors affecting student’s learning location. official study carried out an online survey through Google forms using a questionnaire with participation of 125 samples. Bayesian Model Selection shows that 03 are student studying location (SSL), which Students’ perception (PP), Price (PRI), Perception universities in big city (UNI). From results, we have...

The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect of proinflammatory cytokines on P450 isoenzymes in human hepatocytes has been examined by ...