Electrocyclic reaction product of 1-(methoxycarbonyl)-1,2-dihydropyridine was stereospecifically converted by RuO(4) oxidation into azetidine-cis-2,3-dicarboxylic acid.

Several oligomers constructed with (1R,2S)-2-aminocyclobutane-1-carboxylic acid and glycine, β-alanine, and γ-amino butyric acid (GABA), respectively, joined in alternation have been synthesized and studied by means of NMR and CD experiments as well as with computational calculations. Results account for the spacer length effect on folding and show that conformational preference for these hybri...

In silico screening was performed to search for binary solids in which a phenylpiperazine-derivative drug was cocrystallized with a dicarboxylic acid. The phenylpiperazine derivative could be any of 61 such drugs, while the dicarboxylic acid could be any of nine such acids. The uniqueness of this approach was that two criteria had to be fulfilled simultaneously, namely a high propensity for coc...

The metabolism of benzo[a]pyrene (BP) is known to lead to a large number of oxygenated compounds, some of which can bind covalently to DNA. We have studied the integrated metabolism of BP in vivo in germ-free rats given (14)C-labeled BP. Urinary metabolites were separated into groups according to acidity using lipophilic ion exchangers. The groups were analyzed by mass spectrometry and were fur...

A series of isoquercitrin (quercetin-3-O-β-d-glucopyranoside) esters with mono- or dicarboxylic acids was designed to modulate hydro- and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica), which accepted C₅- to C12-dicarboxylic acids; the shorter ones, such as oxalic (C₂)...

Biosynthesis of griseolic acids, competitive inhibitors of cyclic nucleotide phosphodiesterase, was investigated with the culture of a producing strain of Streptomyces griseoaurantiacus. 13C-Labeled and 15N-labeled compounds were added into the culture, and 13C-enriched and 15N-enriched griseolic acid A was isolated from the culture medium and analyzed by 13C NMR and 15N NMR spectroscopy. The c...

The performance of non-fullerene, polymer bulk heterojunction (BHJ) organic photovoltaic devices has a significant correlation with the molecular morphology donor and acceptor. authors show that small molecules coordinated to metal oxide, an electron transport seed layer (ETSL), can profoundly modify donor:acceptor inverted (OPV) devices. Using grazing incidence wide angle X-ray scattering (GIW...

In this study, isophthalic acid-zirconium(IV) nanocomposite has been prepared from zirconyl nitrate pentahydrate and potassium iodide, with isophthalic acid, (C8H6O4=Benzene-1,3-dicarboxylic acid) as a ligand, via sonochemical method in ethylene glycol and methanol as solvents. The crystalline tetragonal ZrO2 has been produced by thermal decomposition of isophthalic acid-zirconium(IV) nanocompo...

Epoxy/dicarboxylic acid vitrimer was prepared by the solvent-free reaction of diglycidyl ether bisphenol A (DGEBA) and 1,4-cyclohexane dicarboxylic (CHDA) with addition monobutyltin oxide (Sn) as a catalyst. By tailoring catalyst content (?5 mol %), an effective conversion functional groups during cure demonstrated network polymerization mechanisms sequence side reactions. Indeed, manufactured ...