Wells–Dawson tungsten heteropolyacid (H6P2W18O62) has been applied as an effective heterogeneous catalyst for one-pot synthesis of spiro[4H-pyran-3,3’-oxindoles] via reaction of various isatins, malonitrile and 1,3-dicarbonyl compound in water. The corresponding products were obtained in high yields. The catalysts were easily recycled and reused without loss of their catalytic activity. 

Abstract The base-catalyzed reaction of diethyl 1,3-acetonedicarboxylate with 2-hydroxybenzylidene indenediones was studied. provides a facile and expeditious protocol for the synthesis natural product inspired fluorenone-fused coumarins in good to very yields. This process resembles combination domino Michael–intramolecular Knoevenagel–aromatization–lactonization reactions single step. Althoug...

Free radicals and oxidants may cause various damages both to the lifeworld different products. A typical solution for prophylaxis of oxidation-caused conditions is usage antioxidants. Among them, classes are found—polyphenols, conjugated polyalkenes, some sulfur nitrogen derivatives. Regarding active site in molecules, a widely discussed group compounds 1,3-dicarbonyl compounds. them natural (e...

A simple deep eutectic solvent based on tin (II) chloride was used as a dual catalyst and environmentally benign reaction medium for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives, from aromatic and aliphatic aldehydes, 1,3-dicarbonyl compounds, and urea in good-to-excellent yields and short reaction time. This simple ammonium deep eutectic solvent, easily synthesized from...

The thiating effect of 1,3,2,4-dithiadiphosphitane2,4-bis(4-methoxyphenyl)-2,4-disulfide (1) on car­ bonyl compounds, leads to the formation of their thio-analogous [1—4], We have recently reported on the reaction of 1 with acetamides [5] and dicarbonyl compounds [6]. On the other hand, there are no compounds having o-diazo-thiono groups were re­ corded in the literature. Based on this findings...

A new approach for the synthesis of 1,4-dicarbonyl compounds is reported. Chemoselective activation of amide carbonyl functionality and subsequent umpolung via N-oxide addition generates an electrophilic enolonium species that can be coupled with a wide range of nucleophilic enolates. The method conveys broad functional group tolerance on both components, does not suffer from formation of homoc...

The reductive coupling of enones or enals with alkynes, followed by olefin oxidative cleavage and Paal-Knorr cyclization, provides a versatile entry to a variety of pyrrole frameworks. A number of limitations of alternate entries to the requisite 1,4-dicarbonyl intermediate are avoided. Classes of pyrroles that are accessible by this approach include 2,3-, 2,4-, 1,2,3-, 1,2,4-, 2,3,5-, and 1,2,...

The syntheses of quinoxalines derived from 1,2-diamine and 1,2-dicarbonyl compounds under mild reaction conditions was carried out using a nanoparticle-supported cobalt catalyst. The supported nanocatalyst exhibited excellent activity and stability and it could be reused for at least ten times without any loss of activity. No cobalt contamination could be detected in the products by AAS measure...

A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium acetate that formed magnesium enolate in situ. Although electron-deficient trifluoroacetoacetate did not undergo this cycloaddition under the ...