Inflammation and infection downregulate the activity and expression of cytochrome P450s (P450s) and other drug metabolizing enzymes (DMEs) involved in hepatic drug clearance. Schistosoma mansoni infection was reported to cause a downregulation of hepatic P450-dependent activities in mouse liver, but little is known about the specific enzymes affected or whether phase II DMEs are also affected. ...

Nitrogen-bridged donor-acceptor multifused dithienopyrrolobenzothiadiazole (DTPBT) and dibenzothiadiazolopyrrolothiophene (DBTPT) were successfully synthesized by intramolecular Cadogan annulation. The electron-deficient benzothiadiazole unit in DTPBT can be converted to benzoselenadiazole and quinoxaline moieties through reduction/cyclization to generate dithienopyrrolobenzoselenadiazole (DTPB...

Acinar cell tumors of the pancreas are uncommon and they include acinar cell carcinomas, acinar cell cystadenocarcinomas and acinar cell cystadenomas (ACCs) (1-5). These tumors are composed of typical round or cylindrical cells with eosinophilic periodic acid stain (PAS)positive cytoplasmic granules. On immunohistochemical analysis, they express pancreatic enzymes, and electron microscopy demon...

hie-124 is a new member of ultra-short acting hypnotics’ drug family. in this research, the synthesis ofanalogues of hie-124 drug in the heterocyclic thiazole ring replaced to thiadiazole, will be presented.thiadiazolodiazepines during a two-step reaction starting from the amino thiadiazole resultedfrom-various derivatives of benzoic acid and thiosemicarbazide were synthesized. in the first ste...

Hiring and Firing Costs, Adverse Selection and Long-Term Unemployment * In this paper, we present a matching model with adverse selection that explains why flows into and out of unemployment are much lower in Europe compared to North America, while employment-to-employment flows are similar in the two continents. In the model, firms use discretion in terms of whom to fire and, thus, low quality...

Picene, which is an organic p-channel semiconductor and a component of superconductors, was derivatized with a thiadiazole-dioxide moiety to afford a novel acceptor molecule (PTDAO₂). PTDAO₂ can form stable anion radical species in solution and as a crystal, and its neutral crystalline thin film exhibits n-type transistor characteristics.

The 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole set are well known compounds with interesting in vitro and in vivo anti-cancer profiles. The aim of this study was an in vitro evaluation of the anti-cancer activity of a new synthesized aminothiadiazole derivative 2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)- -1,3,4-thiadiazole 4ClABT. The effect on tumor cell proliferation, motility an...

A number of new substituted 1,2,4-triazole, 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazine derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes). The synthesized compounds displayed different degrees of antimicrobial ac...

The molecular structure of a macrocycle with a 24-membered ring, a thiadiazole-containing expanded heteroazaporphyrinoid, has been, for the first time, directly characterised by a synchronous gas electron diffraction and mass spectrometric experiment and DFT calculations; the molecule has the equilibrium structure of C(3h) symmetry with a planar macrocycle.