Expression of miR-137 is downregulated in brain tissue from patients with depression and suicidal behavior, and is also downregulated in peripheral blood from stroke patients. However, it is not yet known if miR-137 acts as a bridge between stroke and depression. To test this, we used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats. C...

MIR137, transcribed as the microRNA miR-137, is one of the leading candidate schizophrenia susceptibility genes to arise from large genome-wide association studies (GWAS) of the disorder. Recent data suggest that miR-137 modulates the expression of other schizophrenia susceptibility genes. Although bioinformatic resources are available with which to predict genes regulated by individual microRN...

In this study ultra performance liquid chromatography (UPLC) coupled to time-of-flight mass spectrometry in the MS(E) mode was used for rapid and comprehensive analysis of metabolites in the serum of mice exposed to internal exposure by Cesium-137 ((137)Cs). The effects of exposure to (137)Cs were studied at several time points after injection of (137)CsCl in mice. Over 1800 spectral features w...

This study used particle size analysis to investigate the initial accumulation and trap efficiency of radiocesium ((137)Cs) in four irrigation ponds, ~4-5 months after the Fukushima Dai-ichi nuclear power plant (DNPP) accident. Trap efficiency, represented by the inventory of (137)Cs in pond sediment to the inventory of radiocesium in soil surrounding the pond (i.e., total (137)Cs inventory), w...

Mushrooms are known to accumulate radiocesium. To estimate the intake of radiocesium through the eating of mushrooms, about 30 samples belonging to 4 commonly consumed species (Lentinula edodes, Hypsizigus marmoreus, Grifola frondosa, and Tricholoma matsutake), were analyzed for (137)Cs and (40)K. The concentration ranges were 0.060-29 Bq kg(-1) (wet wt) for (137)Cs and 38-300 Bq kg(-1) (wet wt...

The fate of (137)Cs derived from the Fukushima nuclear accident fallout and associated radiological hazards are largely dependent on its mobility in the surface soils of forest ecosystems. Thus, we quantified microbial and adsorptive retentions of (137)Cs in forest surface (0-3 cm) soils. The K(2)SO(4) extraction process liberated 2.1%-12.8% of the total (137)Cs from the soils. Two soils with a...

Micropthalmia-associated transcription factor (MITF) is the master regulator of melanocyte development, survival, and function. Frequent alteration in the expression of MITF is detected in melanoma, but the mechanism(s) underlying the alteration in expression have not been completely determined. In these studies, we have identified microRNA-137 (miR-137) as a regulator of MITF expression. The g...

BACKGROUND In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs). METHODS We first used a computational target prediction analysis to identify 6 candidate miRNAs that bind to the 3'-untran...