MST4, a member of the Sterile 20 serine/threonine kinase family, was found to be expressed in prostate carcinoma tumor samples and cell lines. In addition, expression levels appeared to correlate with tumorigenicity and androgen receptor status of the cells. Ectopic expression of wild-type and kinase-inactive MST4 was used to alter cellular MST4 activity levels in three widely studied human pro...

Genomic signaling mechanisms require a relatively long time to get into action and represent the main way through which steroid hormones affect target cells. In addition, steroids may rapidly activate cellular functions by non-genomic signaling mechanisms involving membrane sites. Understanding in depth the molecular mechanisms of the non-genomic action represents an important frontier for deve...

BACKGROUND The inhibitory effects of black cohosh extracts (Cimicifuga syn. Actaea racemosa L.) on the proliferation of human breast cancer cells were reported recently. In this study, we turned examined another hormone-dependent, epidemiologically important tumor disease, prostate cancer. The cell growth inhibitory effect of an isopropanolic extract of black cohosh (iCR) on androgen-sensitive ...

MUC1 mucin is transcriptionally regulated by estrogen, progesterone, and glucocorticoids. Our objective was to determine whether androgen receptor (AR) activation regulates expression of MUC1. The following breast and prostatic cell lines were phenotyped and grouped according to AR and MUC1 protein expression: 1) AR+MUC1 + [DAR17+19 (AR transfectants of DU-145), ZR-75-1, MDA-MB-453, and T47D]; ...

سلج 36 روم 07 / 02 / 94 و يس و دصكي نيمشش يشهوژپ ياروش هسلج تروص 1 . هسلج ليكشت تعاس و خيرات ،زور : زور هبنشود خيرات هب 07 / 02 / 94 هسلج نامز تدم 2 زا تعاس 14 تياغل 16 2 . يدعب هسلج خيرات : 28 / 02 / 94 3 . هسلج ليكشت لحم : يشهوژپ تنواعم رتفد 4 . هسلج رد هدننك تكرش ءاضعا : 1 ناراجشا يلع رتكد 2 رتكد يمولظم يلع رف 3 رفدنمجرا سابع رتكد 4 يرفعج دمحم رتكد يدنره 5 يضاق ديعس رتكد يبرغم ...

* لوئسم هدنسيون : فيرـش نابايخ ،ناهفصا يوـك ،يـفقاو نب ،يناطلس نسحم ديهش حرف تسب كلاپ ،شخب 10 / 8 نفلت : 3168058 0913 email: [email protected] فده و هنيمز : ميزنآ نيرتمهم زا زانژيسكا ولكيس ميزنآ نيدنلاگاتسورپ زتنس ريسم ياه ا شياديپ و اه ندب رد باهتل تسا ناسنا . هزات رد رثا تاقيقحت نيرت ت رخ ي زانژيسكا ولكيس ميزنا زا يب 2 لولس رب هدش هديد ناسنا زغم يبصع ياه ب تسا ه يروط...

BACKGROUND Recombinant human arginase (rhArg) has been developed for arginine deprivation therapy in cancer, and is currently under clinical investigation. During pre-clinical evaluation, rhArg has exhibited significant anti-proliferative activity in cancer cells deficient in the expression of ornithine carbamoyl transferase (OCT). Interestingly, a variety of cancer cells such as melanoma and p...

مداخل يعسوت رامعم ميمصت " ةجاحلا بسح ةددعتم طئاسو " ABSTRACT in this paper we develop a Vhdlbased scalable architecture of a multimedia on demand server model. Te three server subsystems are:the control subsystem, the communication subsystem and the storage subsystem are modeled. The communication subsystem is designed as an interconnection network with meshed-pipe structure and delivers packe...

Objective: To investigate the effect of ARA55 over-expression on the prostate cancer proliferation, aggression and apoptosis; to investigate whether ARA55 can regulate the expression of TGF-β or Smad7 in prostate cancer cells, and its relationship with estrogen receptor. Methods: The expression of ARA55, estrogen receptor α (ERα), ERβ, TGF-β and Smad7 was detected in human prostate cancer tissu...