BACKGROUND Depression and cognitive impairment (CI) are important non-motor symptoms in Parkinson's Disease (PD) and related syndromes, but it is not clear how well they are recognised in daily practice. We have studied the diagnostic performance of experienced neurologists on the topics depression and cognitive impairment during a routine encounter with a patient with recent-onset parkinsonian...

We performed a retrospective chart review for 149 randomly selected well-child encounters to evaluate the frequency with which clinicians plot growth measurements and document growth abnormalities during health maintenance visits. Providers failed to plot at least one measurement of height, weight, and/or head circumference in 31 of 149 encounters (21%, 95% CI = 14.5% to 27.5%). Growth abnormal...

MicroRNAs (miRNAs) are small RNAs which potent regulators of gene expression and have been implicated in the regulation inflammatory responses psoriasis. Psoriasis is a chronic skin disease characterized by disturbed interplay between immune cells keratinocytes maintaining vicious circle inflammation. Previously, we identified miR-149 as miRNA significantly suppressed psoriasis lesions showed t...

Clinical and experimental data have demonstrated that genetic factors play an important role in determining the susceptibility to ischemic stroke (IS). The present study was performed to clarify the association between the pre-microRNA-149 (miR-149) single nucleotide polymorphism rs71428439 and the risk of IS in the Jiangsu Han population. Polymerase chain reaction and restriction fragment leng...

24 The emergence of drug-resistant herpesviruses represents a significant problem in clinical practice, primarily 25 in immunocompromised patients. Furthermore, effective antiviral therapy against gammaherpesvirus26 associated diseases is lacking. Here, we present two thiothymidine derivatives, KAY-2-41 and KAH-39-149, 27 with different spectrum of antiviral activity compared to reference anti-...

The emergence of drug-resistant herpesviruses represents a significant problem in clinical practice, primarily in immunocompromised patients. Furthermore, effective antiviral therapies against gammaherpesvirus-associated diseases are lacking. Here, we present two thiothymidine derivatives, KAY-2-41 and KAH-39-149, with different spectra of antiviral activity from those of the reference antiherp...