Drospirenone (DRSP), a progestin with antialdosterone activity, has been developed for hormone therapy in combination with 17-estradiol (E2) in postmenopausal women. We evaluated the antihypertensive efficacy and safety of various doses of DRSP and E2 and estradiol alone in postmenopausal women with hypertension using ambulatory and clinic blood pressure (BP) monitoring. This was a randomized, ...

Ling, Shanhong, Peter J. Little, Maro R. I. Williams, Aozhi Dai, Kazuhiko Hashimura, Jun-Ping Liu, Paul A. Komesaroff, and Krishnankutty Sudhir. High glucose abolishes the antiproliferative effect of 17 -estradiol in human vascular smooth muscle cells. Am J Physiol Endocrinol Metab 282: E746–E751, 2002. First published December 4, 2001; 10.1152/ajpendo.00111.2001.—We examined effects of 17 -est...

The placenta is the exchange organ between the mother and the fetus. The inadequate function of this organ is associated with a number of pregnancy disorders. Hypoxia and oxidative stress during placental development may induce endothelial dysfunction, resulting in the reduction in the perfusion of the placenta. During pregnancy, the levels of estrogen are increased. Decreased estrogen levels h...

STEPHEN M. ROTH, RICHARD GAJDOSIK AND BRENT C. RUBY. Effects Of Circulating Estradiol On Exercise-Induced Creatine Kinase Activity. JEPonline. 2001;4(2):10-17. The present investigation sought to determine the effects of circulating estradiol (E2) and oral contraceptive use on serum creatine kinase (CK) activity following acute eccentric exercise. Ten college-aged female subjects were grouped a...

Type 2 diabetes causes structural and functional changes in the myocardium, which is called cardiomyopathy. Diabetic cardiomyopathy (DCM) is a distinct primary disorder process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Also, DCM is a multifaceted disorder that is one of the leading causes of death in elderly and postmenopausal women. Menopause i...

Booth EA, Lucchesi BR. Medroxyprogesterone acetate prevents the cardioprotective and anti-inflammatory effects of 17 -estradiol in an in vivo model of myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol 293: H1408–H1415, 2007. First published April 13, 2007; doi:10.1152/ajpheart.00993.2006.—Previous studies demonstrated the protective effects of estrogen administration in model...

The characterization and potential of mesenchymal stem cells (MSCs) are gender dependent and estrogen influences these properties. This study demonstrated that supplementation with 17β-estradiol (E2) increases the proliferation of bone marrow-MSCs derived from male and female mini-pigs (Mp- and Fp-BMSCs) in a concentration-dependent manner, with 10(-12) M E2 suggested as the optimal dose of E2 ...

Two experiments were conducted at three locations to determine the correct dosage and carrier for trenbolone acetate (TBA) and estradiol (E2) implants in feedlot steers. In the dose-response experiment, 1,296 steers were allotted to six implant treatments (48 pens per location): control, 140 mg of TBA (140/0), 30 mg of E2 (0/30), 20 mg of TBA + 4 mg of E2(20/4), 80 mg of TBA + 16 mg of E2(80/16...

The purpose of this study was to investigate the effects of 17-β-estradiol (E2)-induced reactive oxygen species (ROS) on the induction of mammary tumorigenesis. We found that ROS-induced by repeated exposures to 4-hydroxy-estradiol (4-OH-E2), a predominant catechol metabolite of E2, caused transformation of normal human mammary epithelial MCF-10A cells with malignant growth in nude mice. This w...

Aims Test the putative contribution of 17-β-estradiol in the development of spreading depression (SD) events and head pain in awake, non-restrained rats. Main Methods Female, Sprague-Dawley rats were intact or underwent ovariectomy followed one week later by surgery to place electrodes onto the dura to detect epidural electroencephalographic activity (dEEG). dEEG activity was recorded two day...