Under the usual circumstance of ingestion of an acid ash diet the normal individual is faced with a deficit of available base. Those stores of circulating bicarbonate which enter the glomerular filtrate along with other crystalloids of the plasma are carefully conserved; only minute amounts are lost in the urine. But when an alkaline ash diet is ingested or sodium bicarbonate is administered, s...

Under the usual circumstance of ingestion of an acid ash diet the normal individual is faced with a deficit of available base. Those stores of circulating bicarbonate which enter the glomerular filtrate along with other crystalloids of the plasma are carefully conserved; only minute amounts are lost in the urine. But when an alkaline ash diet is ingested or sodium bicarbonate is administered, s...

We describe here a simple, rapid chromatographic procedure for quantitatively separating serum creatine kinase isoenzymes (EC 2.7.3.2), with diethylaminoethyl (DEAE)-Sepharose CL-6B as the anion-exchanger. We established the column bed height and the elution parameters by use of a simplex procedure. DEAE-Sepharose CL-6B equilibrated in tris(hydroxymethyl)aminomethane (50 mmol/L, pH 7.5, and con...

BACKGROUND Nutritional rickets remains prevalent in many tropical countries despite the fact that such countries have ample sunlight. Some postulate that a deficiency of dietary calcium, rather than vitamin D, is often responsible for rickets after infancy. METHODS We enrolled 123 Nigerian children (median age, 46 months) with rickets in a randomized, double-blind, controlled trial of 24 week...

introduction: the need for food produced from animal husbandry has made it a growing industry which result in increment of livestock waste. on the basis of environmental and economic considerations, these materials require treatment and management. anaerobic digestion and creation of biogas are the most effective methods of waste management. several parameters affect the anaerobic digestion of ...

considered to be the cleanest liquid fuel, bioethanol can be a reliable alternative to fossil fuels. it is produced by fermentation of sugar components of plant materials. the common onions are considered to be a favorable source of fermentation products as they have high sugar contents as well as contain various nutrients. this study focused on the effective production of ethanol from an endem...

Copyright © 2007 Massachusetts Medical Society. A 68-year-old accountant visits his physician. He was told a year earlier that his blood pressure was somewhat elevated and was advised to reduce salt intake and increase physical activity. Otherwise he has been in good health and has no history or signs of cardiovascular or renal disease. On physical examination, his blood pressure is 178/72 mm H...

N Engl J Med 2003;348:1456-63. Copyright © 2003 Massachusetts Medical Society. A 71-year-old woman who had a myocardial infarction five years previously and underwent coronary-artery bypass surgery six months ago visits a primary care physician. She had no complications after surgery, but intraoperative transesophageal echocardiography revealed a grade V atheroma in the descending aorta. She ha...

Copyright © 2012 Massachusetts Medical Society. A 39-year-old man with a 2-year history of type 2 diabetes mellitus presents for care. He has no microvascular or macrovascular complications. His family history is positive for type 2 diabetes and cardiovascular disease in his mother and older brother. On examination, his weight is 99.8 kg (220 lb), with a body-mass index (BMI; the weight in kilo...

BACKGROUND Proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases, binds to low-density lipoprotein (LDL) receptors, leading to their accelerated degradation and to increased LDL cholesterol levels. We report three phase 1 studies of a monoclonal antibody to PCSK9 designated as REGN727/SAR236553 (REGN727). METHODS In healthy volunteers, we performed two randomized, sing...