Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment, and decipher the mechanism of action. We found that miR-96/miR-182 downregulate Palladin protein levels, thereby reducing breast cancer c...

Metastasis is a multi-step process. Tumor cells occur epithelial-mesenchymal transition (EMT) to start metastasis, then, they need to undergo a reverse progression of EMT, mesenchymal-epithelial transition (MET), to colonize and form macrometastases at distant organs to complete the whole process of metastasis. Although microRNAs (miRNAs) functions in EMT process are well established, their inf...

Inactivated LRRC4 has been clinically detected in gliomas, and promoter hypermethylation has been implicated as the mechanism of inactivation in some of those tumors. Our previous researches indicated that LRRC4 is a target gene of miR-381, the interaction of miR-381 and LRRC4 is involved in glioma growth. In this study, we demonstrate that LRRC4 is a target gene of the other microRNA, miR-182....

The accretion of planetary bodies like Earth, Moon, Mars, Vesta and other meteorite parent bodies (diameter > 50 kilometers) was quickly followed by melting and metal-silicate differentiation resulting in core formation. The decay of 182 Hf [half-life (T 1/2) ~ 9 million years (Ma)] to 182 W has proved to be a very useful relative chronometer to determine the core formation and silicate differe...

Recently, efforts have been made to develop the use of dissimilar metal welding in industrial components. Pressurized water reactors (PWR) nuclear power plants frequently (DMW) their primary systems (NPP). The selection combination stainless steel and low alloy is adjusted working conditions work high-temperature environments. Nickel-based Inconel 82/182 used as a weld filler GTAW method joinin...

Constraints on the formation history of the Earth are critical for understanding of planet formation processes. (182)Hf-(182)W chronometry of terrestrial rocks points to accretion of Earth in approximately 30 Myr after the formation of the solar system, immediately followed by the Moon-forming giant impact (MGI). Nevertheless, some N-body simulations and (182)Hf-(182)W and (87)Rb-(87)Sr chronol...

Besides the fact that miR-96 and miR-182 belong to the miR-182/183 cluster, their seed region (UUGGCA, nucleotides 2-7) is identical suggesting potential common properties in mRNA target recognition and cellular functions. Here, we used the mRNA encoding Glypican-3, a heparan-sulfate proteoglycan, as a model target as its short 3' untranslated region is predicted to contain one miR-96/182 site,...

Introduction The aim of this study was to investigate the expression levels of microRNA-182 and microRNA-183 and their association with clinicopathological features in patients with osteosarcoma. Material and methods Total RNA was purified from samples and noncancerous bone tissues and then quantitative real-time polymerase chain reaction was applied to evaluate the expression levels of micro...

Memory formation is a complex cognitive function regulated by coordinated synaptic and nuclear processes in neurons. In mammals, it is controlled by multiple molecular activators and suppressors, including the key signalling regulator, protein phosphatase 1 (PP1). Here, we show that memory control by PP1 involves the miR-183/96/182 cluster and its selective regulation during memory formation. I...