Sphingosine kinase (SphK) is a key enzyme in the sphingolipid metabolic pathway responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P). SphK/S1P play a critical role in angiogenesis, inflammation, and various pathologic conditions. Recently, S1P(1) receptor was found to be expressed in rheumatoid arthritis (RA) synovium, and S1P signaling via S1P(1) enhances synoviocyte ...

RATIONALE Triacylglycerols (TG) contain three fatty acyls attached to the glycerol backbone in stereochemically numbered positions sn-1, 2 and 3. Isobaric TG with exchanged fatty acyl chains in positions sn-1/3 vs. sn-2 are referred to as regioisomers and the determination of their regioisomeric ratios is important for nutrition purposes. METHODS Differential mobility spectrometry (DMS) coupl...

Oceanic dimethyl sulfide (DMS) emissions have been recognized as a biological regulator of climate by contributing to cloud formation. Despite decades research, the climatic role DMS remains ambiguous largely because limited observational evidence for DMS-induced condensation nuclei (CCN) enhancement. Here, we report concurrent measurement DMS, physiochemical properties aerosol particles, and C...

The impact of the decline of the vernal bloom on the bacterial metabolism of dimethylsulfoniopropionate (DMSP), the precursor of dimethylsulfide (DMS), was investigated during a 7 d Lagrangian study conducted in the Northwest Atlantic in spring 2003. Daily variations in bacterial leucine incorporation, dissolved DMSP (DMSPd) uptake and DMS production rates were measured in the surface mixed lay...

Semantic Designs champions the view that software engineers typically maintain code, when a more valuable approach would be maintaining the design concepts, the implementation steps and the relation between the two that led to the creation of the code. The Design Maintenance System Software Reengineering Toolkit (DMS SRT) is capable of automating the capture, analysis and transformation of low-...

Abstract. Dimethyl sulfide (DMS) is a naturally occurring aerosol precursor gas which plays an important role in the global sulfur budget, formation and climate. While DMS produced predominantly by phytoplankton, recent observational literature has suggested that corals their symbionts produce comparable amount of DMS, unaccounted for models. It further been hypothesised coral reef source may m...

The influence of solar radiation on springtime rates of photochemical and biological consumption of dimethylsulfide (DMS) in surface waters from the western Atlantic Ocean was examined by exposing 0.2 mm filtered and unfiltered surface seawater to natural sunlight at five depths in the upper 30m. Parallel deck incubations of 0.2 mm filtered seawater under various long-pass optical filters were ...

Key Challenges of Metabolite Separation 1. Metabolite analysis features complex matrices. Samples from plasma and urine are common, but also from in vitro metabolite studies using liver microsomes, possibly causing elevated background signals or isobaric interferences. 2. Enzymatic metabolization often results in a set of isobaric compounds. MS/MS fragmentation can differentiate constitutional ...