In the title compound, C(10)H(8)N(3)S(+)·NO(3) (-)·H(2)O, one of the N atoms of the benzimidazole unit is protonated, unlike than that in the thia-zole group. This protonation leads to equalization of the bond angles at the two N atoms of the benzimidazole group. The benzimidazole and thia-zole systems are almost coplanar, forming a dihedral angle of 0.5 (2)°. In the crystal, the nitrate anion ...

Benzimidazole, a simple heterocycle continues to hold promise to medicinal chemists. A vast number of compounds contain this scaffold and many of these have become blockbusters such as omeprazole, astemizole, candesartan to name a few. Benzimidazoles are unique in that they have been reported to show activity against fungal, mammalian and helminthes cells via binding to microtubules. They are t...

A new benzimidazole compound, C(12)H(14)N(2)O(2), has been synthesized by the reaction of 2-methyl-1H-benzimidazole and ethyl 2-bromo-acetate. In the crystal structure, weak inter-molecular C-H⋯N hydrogen bonds link the mol-ecules into chains. π⋯π Contacts (centroid⋯centroid distance = 3.713 Å) are observed. A C-H⋯π inter-action is also present. The N-C-C-O torsion angle is 178.4 (2)°.

A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally fri...

In the title compound, [Cu(C(11)H(13)N(3))(2)](NO(3))(2)·2H(2)O, synthesized by hydro-thermal reaction of Cu(NO(3))(2) and racemic 2-(pyrrolidin-2-yl)-1H-1,3-benzimidazole, the Cu(II) atom lies on an inversion centre. The distorted octa-hedral Cu(II) environment contains two planar trans-related N,N-chelating 2-(pyrrolidin-2-yl)-1H-1,3-benzimidazole ligands in the equatorial plane and two monod...

In the title compound, C(14)H(21)N(2)Si(+)·Br(-)·H(2)O, the benzimidazole ring system is almost planar [maximum deviation = 0.021 (2) Å]. In the crystal, O-H⋯Br and C-H⋯O hydrogen bonds link the ions via the O atoms of the water mol-ecules. In addition, there are π-π stacking inter-actions between the centroids of the benzene and imidazole rings of the benzimidazole ring system [centroid-centro...

The title compound, C(17)H(18)N(2)O(2)S, was synthesized by aryl-sulfonyl-ation of 1-hy-droxy-methyl-1H-benzimidazole in the presence of triethyl-amine. The benzimidazole and benzene rings form a dihedral angle of 84.1 (1)°. The tert-butyl group was treated as rotationally disordered over two orientations in a 0.51 (2):0.49 (2) ratio. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds li...