This research was performed to investigate the effects of milk thistle (MT), toxin binder (TB) and marine algae (Spirulina platensis; SP) on performance, blood indices, humoral immunity cecal microbiota broiler chickens exposed aflatoxin-B1 (AFB1). A total 300 one-day-old male chicks were equally divided into five treatments, with six replicates 10 birds per treatment. Dietary treatments includ...

Mycotoxins are harmful auxiliary metabolites delivered by species of filamentous organisms developing on grains some time recently collect and in capacity. The study was planned to evaluate the protective role lycopene (LYC) against Aflatoxin B1 (AFB1) induces oxidative stress, hepatic toxicity, apoptosis Japanese quail. Sixty quail chicks (three-week-old) were randomly allocated into four grou...

Nephrotoxicity remains a common untoward effect of cisplatin therapy with limited effective chemopreventive options available till date. This study aims to evaluate the possible chemopreventive effect and mechanism(s) of action of 2 mgkg-1 and 5 mgkg-1 of Tadalafil in cisplatin-induced nephrotoxic rats. In this study, twenty-five male Wistar rats were randomly divided into five groups (n = 5 ra...

A variety of moulds routinely infect the world’s cereal crops. Under certain field or storage conditions, some moulds can produce toxin metabolites “mycotoxins“. Aflatoxins (AFs) are a group of highly carcinogenic mycotoxins produced primarily by the fungus Aspergillus flavus. Within the group of AFs, Aflatoxin B1 (AFB1) have been reported to be carcinogenic, teratogenic, tremorgenic, and derma...

The effect of phenobarbital (PB) pretreatment of rats on both hepatic aflatoxin B1 (AFB1)-DNA binding and AFB1-glutathione (AFB1-SG) conjugation have been examined in studies in vivo and in vitro. Male Sprague-Dawley rats fed a commercial diet with 0.1% PB in their drinking water for 1 week had total wet liver weight and microsomal protein content about 27% and 38% higher, respectively, than co...

The study objectives were (a) to correlate AFB1 serum albumin adduct levels with AFB1-DNA adduct levels in liver in different rodent species to determine whether the former could serve as a marker of hepatic DNA adduct levels irrespective of species, and (b) to relate the levels of both adducts to differences in susceptibility to tumor induction by AFB1 in the different species. Finally, an att...

The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg⁻¹d⁻¹ LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cyt...

Background: This study aims to evaluate the efficacy of silybum marianum seeds (SMSs) on blood biochemical profile of broiler chickens contaminated with Aflatoxin B1 (AFB1).  Methods: Combinations of three levels of AFB1 (0, 250 and 500 ppb) with three levels of SMSs (0, 0.5, and 1.0 %) were incorporated into the basal diet (corn and soybean meal). The effect of nine experimental treatments was...

Background: This study was conducted to determine the efficacy of milk thistle seeds (MTSs) in counteracting the toxic effects of aflatoxin B1 (AFB1) in a contaminated diet fed to broilers.Methods: Two dietary inclusion rates of AFB1 (0, 0.250 and 500 ppb) and MTS (0, 0.5 and 1%) were tested in a 3×3 factorial manner. The effect of nine experimental treatments was assessed using 216 one-d-old R...

background: this study was conducted to determine the efficacy of milk thistle seeds (mtss) in counteracting the toxic effects of aflatoxin b1 (afb1) in a contaminated diet fed to broilers.methods: two dietary inclusion rates of afb1 (0, 0.250 and 500 ppb) and mts (0, 0.5 and 1%) were tested in a 3×3 factorial manner. the effect of nine experimental treatments was assessed using 216 one-d-old r...