نتایج جستجو برای: 21 cell
تعداد نتایج: 1893331 فیلتر نتایج به سال:
To evaluate the effects of polyphyllin D on proliferation and apoptosis human colon cancer SW480 cell lines to reveal whether this process is mediated by micro ribonucleic acid-21/phosphatase tensin homolog deleted chromosome 10 pathway. Human cells were transfected with acid-21-mimic or mimic-negative control treated at different concentrations (control, 0.25, 0.5, 1 2 μM) for 24 h 48 h. Compa...
PURPOSE MicroRNA-21 (miR-21) is abnormally expressed in many solid cancers, such as gastric adenocarcinoma, and regulates some targets involved in cancer initiation and progression. In this study, we investigated the function of miR-21 in two gastric cancer cell lines, as well as its potential targeting of the tumor suppressor genes phosphatase and tensin homolog (PTEN) and programmed cell deat...
In cutaneous T cell lymphomas (CTCL), miR-21 is aberrantly expressed in skin and peripheral blood and displays anti-apoptotic properties in malignant T cells. It is, however, unclear exactly which cells express miR-21 and what mechanisms regulate miR-21. Here, we demonstrate miR-21 expression in situ in both malignant and reactive lymphocytes as well as stromal cells. qRT-PCR analysis of 47 pat...
Osteosarcoma is the most common primary bone tumor and poor prognosis for osteosarcoma patients is mainly due to chemotherapy resistance. MicroRNAs are important to maintain pathophysiological mechanisms of cancer and influence cell sensitivity to chemotherapy. In this study, we tested the functions of microRNA-21 for malignant features as well as for drug resistance of osteosarcoma. We used No...
Abstract Background B cells play an important role in the immune system due to production of the immunoglobulin and secreting several cytokines. It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L). IL2, IL7, and IL15 cytokines as -common family have an essential cytokines may support either synergistically or in an additive m...
Axin2 loss, we are over-expressing a drug-stabilised b-catenin construct in wild-type skull osteoblast cultures, and in skull explant (calvarial) cultures. Using a drug-dependent b-catenin will allow us to investigate the threshold levels of Wnt signalling required for ossification and the stages at which the b-catenin signal is critical for osteoblast differentiation. Our findings from these i...
AIMS This study is to investigate the regulatory effect of microRNA-21 (miR-21) on bone metastasis of non-small cell lung cancer (NSCLC). METHODS In this study, 18 patients were diagnosed with vertebral column metastasis of NSCLC. MiR-21 or small interfering RNAs were transfected into H2170 cells using Lipofectamine 2000. Real-time PCR was performed to detect miR-21 expression. Western blotti...
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