BACKGROUND Exclusive breastfeeding up to the completion of the sixth month of age is the national infant feeding recommendation for Sri Lanka. The objective of the present study was to collect data on exclusive breastfeeding up to six months and to describe the association between exclusive breastfeeding and selected socio-demographic factors. METHODS A clinic based cross-sectional study was ...

Plate Boundaries and Natural Hazards, Geophysical Monograph 219, First Edition. Edited by João C. Duarte and Wouter P. Schellart. © 2016 American Geophysical Union. Published 2016 by John Wiley & Sons, Inc. “With firm geological foundations and major earthquakes rare, Fukushima is a safe and secure place to do business.” Fukushima Prefecture Website [Cyranoski, 2011] Promise and Paradox: Why Im...

Earlier we had shown that the MDM2 inhibitor (MI-219) belonging to the spiro-oxindole family can synergistically enhance the efficacy of platinum chemotherapeutics leading to 50% tumor free survival in a genetically complex pancreatic ductaladenocarcinoma (PDAC) xenograft model. In this report, we have taken a systems and network modeling approach in order to understand central mechanisms behin...

Variations in levels of apolipoprotein E (ApoE) have been tied to the risk and progression of Alzheimer's disease (AD). Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene (APOE) promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here th...

BACKGROUND It has been proposed that, independent of the epsilon4 allele, APOE promoter polymorphisms (-491 A/T and -219 G/T) may be risks factor for Alzheimer's disease by modulating APOE expression. OBJECTIVE To measure the level of APOE expression in Alzheimer's disease. METHODS Brains were obtained at necropsy from 114 patients with early and late onset sporadic Alzheimer's disease in G...

Phosphopeptide mapping identified a major autophosphorylation site, phospho (p)Thr-219, between the tandem C1 domains of the regulatory fragment in protein kinase C (PKC)theta. Confirmation of this identification was derived using (p)Thr-219 antisera that reacted with endogenous PKCtheta in primary CD3+ T cells after stimulation with phorbol ester, anti-CD3 or vanadate. The T219A mutation abrog...

Purpose : Cell-~11 and cell-subsbatum interactions are mediated through different families of receptors in particular integrins. These cell receptors influence many physiological processes including cellular pmlifemtion and differentiation which are implicated in the secondzuy cataract development. The current study reports the distribution of the integrins expressed at the cell surface in a no...

The old calendar of pollens did not reflect current pollen distribution and concentrations that can be influenced by changes of weather and environment of each region in South Korea. A new pollen calendar of allergenic pollens was made based on the data on pollen concentrations obtained in eight regions nationwide between 1997 and 2009. The distribution of pollen was assessed every day at 8 are...

The transcription factor Pit-1/GHF-1 plays an important role in regulating the prolactin (Prl) and growth hormone (GH) genes in mammals. In this study, the role that Pit-1 plays in regulating the prolactin and growth hormone genes in avian species was examined by cotransfection assays and immunofluorescence staining of pituitary sections. In cotransfection assays, turkey Pit-1 activated the tur...