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The aims of the present study were to examine the potential role of microRNA‑233‑3p (miR)‑223‑3p in the tumorigenesis of hepatocellular carcinoma (HCC), and to investigate its diagnostic accuracy and potential molecular mechanisms. The expression data of miR‑223‑3p in HCC were obtained from the Gene Expression Omnibus (GEO). Data for the precursor miR‑223 were obtained from The Cancer Genome At...
BACKGROUND In Alpharadin in Symptomatic Prostate Cancer (ALSYMPCA) trial, radium-223 versus placebo prolonged overall survival with favorable safety in castration-resistant prostate cancer patients with symptomatic bone metastases. Long-term radium-223 monitoring underlies a comprehensive safety and risk/benefit assessment. OBJECTIVE To report updated ALSYMPCA safety, including long-term safe...
BACKGROUND/AIMS Over the past decade, heat shock protein 90 (Hsp90) has emerged as a potential therapeutic target for cancer. However, the molecular mechanisms of down-regulation Hsp90 expression in osteosarcoma are incompletely understood. To develop potential therapy targeting Heat shock protein 90B1 (Hsp90B1), we studied the roles of miR- 223 in the proliferation and apoptosis of human osteo...
C holesterol homeostasis is a tightly regulated process. Previous work has been dominated by sterol-response element—related mechanisms, but the influence of micro-RNAs (miRs) is increasingly recognized, with miR-223 becoming a recent member of this group. Several micro-RNAs (miRNAs or miR-) have been reported to be involved in cholesterol homeostasis. 1–4 In a recent study, Vickers et al 5 pre...
science&justice Volume 42 No.4 (2002) 223 – 224 Page 223 *Corresponding author © The Forensic Science Society 2002
Epigenetic modifications regulate developmental genes involved in stem cell identity and lineage choice. NFI-A is a posttranscriptional microRNA-223 (miR-223) target directing human hematopoietic progenitor lineage decision: NFI-A induction or silencing boosts erythropoiesis or granulopoiesis, respectively. Here we show that NFI-A promoter silencing, which allows granulopoiesis, is guaranteed b...
Mosquitoes are serious biting pests and obligate vectors of many vertebrate pathogens. Their immature larval and pupal life stages are a common feature in most tropical and many temperate water bodies and often form a significant proportion of the biomass. Control strategies rely primarily on the use of larvicides and environmental modification to reduce recruitment and adulticides during perio...
(a) P is a nonempty set; (b) ≤ is a partial ordering of P; i.e., ≤ is transitive, reflexive relation in P (and so p ≤ q ∧ q ≤ p ∧ p 6= q is not forbidden); (c) for all p ∈ P, p ≤ 1. (1 need not be the only such maximum element.) We shall often write P for 〈P,≤,1〉. Let P be a poset. If p is an element of P, then an extension of p is a q ∈ P such that q ≤ p. Two elements of P are compatible if th...
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216 1. Presentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216 2. Prevalence . . . . . . . . . . . . . . . . . . . ....
1 Department of Clinical and Toxicological Analysis, University of Alfenas-MG, Av. Gabriel Monteiro da Silva, 714, Alfenas, MG, Brazil, 37130.000 2 Laboratory of Industrial Hygiene and Toxicology, University of Brescia, P.le Spedali Civili, 1, 25100, Brescia, Italy 3 Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes...
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