An effective mechanism for interfering with prolactin signalling would provide a powerful tool for clarifying the importance of prolactin in breast cancer, as well as for investigating functions of prolactin in other tissues. Based on our previous identification of a dominant-negative mutation in the growth hormone receptor that causes familial short stature, we investigated the potential for u...

Samuel Hahnemann, the founder of homoeopathy, over a period of 33 years wrote four medical theses at three different universities. The first, in 1779 at the University of Erlangen, Franconia, dealt with agents that allegedly induce spasms, granting him a MD degree. The second two theses in 1784 dealt with obstetrical matters and were imposed upon him by the University of Wittenberg, Saxony, for...

We have obtained Johnson U, B, V and Cousins R, I photometry and low resolution spectra of a small sample of hot post-AGB candidates. Using the present data in combination with JHK data from 2MASS, infrared data from the MSX catalog and the IRAS fluxes, we have studied the spectral energy distribution (SED) of these stars. Using the DUSTY code we have estimated the dust temperatures, the distan...

Status of this Memo This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Abstract This memo describes how to effic...

Hereditary renal carcinomas in the Eker rat are caused by germline retrotransposon insertion in the tuberous sclerosis-2 (Tsc2) gene. We established previously a transgenic Eker rat model into which was introduced a wild-type Tsc2 gene. The embryonic lethality of mutant homozygotes and renal carcinogenesis of heterozygotes were completely suppressed by this transgene (Tg). The function of the T...

The satellite LARES 2 is designed to test dragging of inertial frames, or frame-dragging, predicted by Einstein’s theory General Relativity, with accuracy a few parts in thousand. For this purpose, besides the typical requirements for space construction, high density alloy must be used. In paper are reported studies performed on nickel alloy, Haynes 242, that considered possible candidate manuf...

We investigated the expression of Toll-like receptor 4 (TLR4) in the acute phase of intestinal I/R injury during intussusception and evaluated whether anti-TLR4 antibody-conjugated lead sulfide quantum dots (TLR4-PbS QDs) could be used to detect and monitor the injury. We first established a mouse model of I/R injury during intussusception. TLR-PbS QDs were then intravenously administered to in...