AIM To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. METHODS A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLR4 D299G w...

SRY-box 9 (SOX9) is an important transcription factor required for development, which has additionally been reported to be an independent prognostic indicator for the survival of patients with non‑small cell lung cancer (NSCLC). Accumulating evidence has indicated that dysregulation of microRNAs (miRNAs/miRs) may contribute to the initiation and progression of cancer. SOX9 may be regulated by a...

Nearly all mungbean cultivars are completely susceptible to seed bruchids (Callosobruchus chinensis and Callosobruchus maculatus). Breeding bruchid-resistant mungbean is a major goal in mungbean breeding programs. Recently, we demonstrated in mungbean (Vigna radiata) accession V2802 that VrPGIP2, which encodes a polygalacturonase inhibiting protein (PGIP), is the Br locus responsible for resist...

The genetic diversity in the Kilakarsal sheep population was analysed using 25 microsatellite markers by multiplex PCR in five panels and automated DNA sequencer. The number of alleles ranged from 3 to 13 with a mean of 7.6 across loci. The mean effective number of alleles was 3.88. The size and frequencies of the alleles ranged from 80 to 278 bp and from 0.0100 to 0.8000, respectively. The PIC...

The red fox, Vulpes vulpes (Canidae), is the most widely distributed terrestrial carnivore worldwide, but this species is classified as endangered in Korea. In this study, we developed 25 polymorphic microsatellite markers that included 3-13 (mean = 6.32) alleles per locus using 22 red fox individuals. The most polymorphic locus was FR(59)TG (13 alleles) and the least polymorphic loci were FR(7...

Vaccines that elicit CD8(+) T-cell responses are routinely tested for immunogenicity in nonhuman primates before advancement to clinical trials. Unfortunately, the magnitude and specificity of vaccine-elicited T-cell responses are variable in currently utilized nonhuman primate populations, owing to heterogeneity in major histocompatibility (MHC) class I genetics. We recently showed that Maurit...

almond (prunus dulcis [webb] d.a. mill) is an economically important species of genus prunus (rosaceae, subfamily prunoideae). the commercial edible part of almond fruit is kernel. fertilization is essential for nut production in almond but most cultivars are self or even cross-incompatible. self-incompatibility in almond is gametophytic and controlled by a single s-locus with multiple codomina...

one hundred and twenty iranian accessions of aegilops crassa with origin from different geographical areas of iran, were evaluated for variation in high molecular weight glutenin subunit (hmw-gs) composition. the results showed different banding patterns between hexa (6x) and tetra-ploid (4x) as well as within different ploidy accessions. eleven allelic variants were observed in glu- dcr1 locus...

The joint probability between two binary strings of different lengths has been demonstrated as a suitable basis for a correlation attack on the shrinking generator when the decimation probability is 0.5. As an extension of this, further computer simulations have been conducted to determine whether the joint probability can be used as a basis of similar correlation attacks on irregularly clocked...

Disrupting mutations affecting the tyrosinase (TYR) gene cause different forms of albinism in mice, humans and several other mammals. Classical genetic studies have already reported five alleles at European rabbit Albino locus, indicated to be part C series, each them with actions on pheomelanin eumelanin production, as well eye colour. A few these been characterised DNA level by sequencing cod...