In the White House, among journalists, and for many political practitioners, the idea of a major “political realignment” that might dramatically reshape the face of American politics remains as tantalizing as ever. But among historians and political scientists, no one needs a weatherman to tell which way the wind is blowing. The long-venerated “realignment” approach to election analysis develop...

Background: Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes. Objective: To investigate the probable association between IL-6 (-174 C/G) and IL-8 (-251 A/T) gene polymorphisms and susceptib...

Stumpe, Thomas, and Jürgen Schrader. Short-term hibernation in adult cardiomyocytes is PO2 dependent and Ca mediated. Am J Physiol Heart Circ Physiol 280: H42–H50, 2001.—The mechanism of myocardial hibernation, the reversible downregulation of contractile activity on reduction of coronary flow with unchanged cardiac energetics, is presently not understood. The oxygen consumption (V̇O2), shorteni...

Porpoise Sounds as Sonar Signals: W. N. Kellogg, Robert Kohler, and H. N. Morris 239_it News and Notes 243 Technical Papers A Computational Procedure for the Isotope Method of Brain Tumor Localization: Alexander Langer and Rqbert Loevinger __ 247 The Solubilization of 4-Dimethylaminoazobenzene (Butter Yellow) in Serum: Charles Wunderly ._ 248 Differential Migration of Rubber by Reversed-Phase P...

Pettinger M, et al. Women’s Health Initiative Investigators. Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women’s Health Initiative randomized trial. JAMA 2003; 290: 1739–1748. 28 Archer DF. The effect of the duration of progestin use on the occurrence of endometrial cancer in postmenopausal women. Menopause 2001; 8: 245–251. 29 de Vries CS...

gene-by-environment interaction studies: revelations and remedies. Epidemiology 2011;22:400–07. 4 Weinberg CR, Shi M, Umbach DM. A sibling-augmented case-only design for assessing multiplicative gene-environment interaction. Am J Epidemiol 2011;174:1183–89. 5 Kistner EO, Shi M, Weinberg CR. Using cases and parents to study multiplicative gene-by-environment interaction. Am J Epidemiol 2009;170:...

background: increased levels of interleukin-8 (il-8) and interleukin-6 (il-6) in acute human brucellosis have been reported. previous studies have shown that the production and level of il-6 and il-8 cytokines are associated with the polymorphism of the encoding genes. objective: to investigate the probable association between il-6 (-174 c/g) and il-8 (-251 a/t) gene polymorphisms and susceptib...

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The stark observation of the coexistence of undernourishment, nutrient deficiencies, and overweight and obesity – the triple burden of malnutrition – is inviting us to reconsider health and nutrition as the primary goal and final endpoint of food systems. Agriculture and the food industry have made remarkable advances in the past decades. However, their development hasn’t entirely fulfilled hea...

Thomas Reid offers a powerful challenge to Hume and his skeptical system. In “Thomas Reid on Epistemic Principles,” William Alston gives an explanation of that challenge and concludes in favor of a Reidian-inspired thesis. I argue, however, that Alston’s thesis is a diluted version of Reid’s radical position, one that Reid’s principles cannot accommodate. Thus, I conclude that, because Alston’s...