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We report a new class of photodynamic molecular beacon (PMB) with tumor specific mRNA-triggered control of singlet oxygen ((1)O(2)) production. The beacon contains a single-stranded oligonucleotide linker that forms a stem-loop structure (hairpin) in which the sequence is an antisense oligonucleotide (AS-ON) complementary to a target mRNA. The stem is formed by the annealing of two complementar...
On March 4, 1999, the Wide-Field Infrared Explorer (WIRE) was launched from Vandenberg Air Force Base on a Pegasus XL launch vehicle into a 540 km orbit with a planned mission duration of four months. WIRE was designed to conduct a deep infrared, extra galactic science survey 500 times more sensitive than the Infrared Astronomy Satellite (IRAS) Faint Source Catalog. The instrument consists of a...
This paper examines the dynamics of the LiCl-KCl system over a range of temperatures in order to understand the local structure surrounding chlorine, which is the common ion in these systems, during molten salt pyro-processing. Chlorine-35 nuclear magnetic resonance (NMR) is sensitive to the local environments of the resonant nuclei and their motion on a diffusive timescale. Thus, it is a good ...
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