Cyclin T1 is a regulatory subunit of a general RNA polymerase II elongation factor known as P-TEFb. Cyclin T1 is also required for Tat transactivation of HIV-1 LTR-directed gene expression. Translation of Cyclin T1 mRNA has been shown to be repressed in human monocytes, and this repression is relieved when cells differentiate to macrophages. We identified miR-198 as a microRNA (miRNA) that is s...

We recently established a two-stage in vitro assay for KSR kinase activity in which KSR never comes in contact with any recombinant kinase other than c-Raf-1 and defined the epidermal growth factor (EGF) as a potent activator of KSR kinase activity (Xing, H. R., Lozano, J., and Kolesnick, R. (2000) J. Biol. Chem. 275, 17276-17280). That study, however, did not address the mechanism of c-Raf-1 s...

abstract background and purpose:the main objectives of this research were to evaluating the application of electrocoagulation process for 198 dye from the aqueous phase and determining the optimum operating conditions to the dye removal using aluminum and iron electrodes. materials and methods:the present study was conducted in bench-scale. the spectrophotometer dr 5000 was used to determine th...

AD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque CCR5, but SCH-C does not. Among the eight residues that differ between the human and macaque versions of the coreceptor, only one, methionine-198, accounts for the insensitivity of macaque CCR5 to inhi...

This work introduces a biochar as novel catalyst prepared from the pistachio hull, and demonstrates its catalytic potential for degrading the reactive red 198 (RR198) dye in catalytic ozonation processes (COPs). The prepared pistachio hull biochar (PHB) was a macroporous, basic material with low specific surface area. PHB had the greatest catalytic potential at an optimal alkaline pH of 10. Sig...

receptors in an endogenous sleep pathway. Nat Neurosci 2002; 5:979–84 44. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M: The 2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. ANESTHESIOLOGY 2003; 98:428 –36 45. Tanifuji Y, Zhang Y, Liao M, Eger EI 2nd, Laster MJ, Sonner JM: Do dopamine receptors mediate part of MAC? An...

We studied the effect of pH on ligand binding in wild-type lactose permease or mutants in the four residues-Glu-269, Arg-302, His-322, and Glu-325-that are the key participants in H(+) translocation and coupling between sugar and H(+) translocation. Although wild-type permease or mutants in Glu-325 and Arg-302 exhibit marked decreases in affinity at alkaline pH, mutants in either His-322 or Glu...

In 1994, Ericsson Mobile Communications launched an initiative to study low-power, low-cost radio interfaces between mobile phones and their accessories. A radio-access solution was sought because it would eliminate the need for cables and overcome lineof-sight restrictions. It was also recognized that a low-cost solution would usher in wireless connectivity for a multitude of new applications ...