p16 is a key regulator of cellular senescence, yet the drivers of this stable state of proliferative arrest are not well understood. Here, we identify 22 senescence-associated microRNAs (SA-miRNAs) in normal human mammary epithelial cells. We show that SA-miRNAs-26b, 181a, 210 and 424 function in concert to directly repress expression of Polycomb group (PcG) proteins CBX7, embryonic ectoderm de...

Today’s leading organizations are investing millions of dollars in Business Process Management (BPM) related services and software products. The BPM area is expected to be a $26B industry next year and grow by at least 12% for the foreseeable future. However, the bulk of BPM research and university-level course offerings are not in the USA. Why is there so little BPM education and research in t...

Four soybean cDNA nodule-specific clones encoding nodulin-23, -26b, -27 and -44 were observed to cross-hybridize under low stringency conditions. Nucleotide sequence analysis revealed that the cDNAs contain three distinct domains: two domains with 70 to 95% homology separated by a third domain unique to each cDNA. Despite a number of nucleotide insertions and deletions, the protein sequences ar...

We present NN-grams, a novel, hybrid language model integrating n-grams and neural networks (NN) for speech recognition. The model takes as input both word histories as well as n-gram counts. Thus, it combines the memorization capacity and scalability of an n-gram model with the generalization ability of neural networks. We report experiments where the model is trained on 26B words. NN-grams ar...

Out-of-sample forecasting experiments are used as an alternative to looking at F-statistics when examining whether money, interest rates or the commercial paper/T-bill spread provide information content for subsequent movements in output, real and nominal personal income, the CPI and the PPI. Here a variable provides information if it improves the forecast of the explained variable. Employing t...

Today the regulatory role of microRNAs (miRs) is well characterized in many diverse cel- lular processes. MiR-based regulation is categorized under epigenetic regulatory mecha- nisms. These small non-coding RNAs participate in producing and maturing erythrocytes, expressing hematopoietic factors and regulating expression of globin genes by post-tran- scriptional gene silencing. The changes in e...