The liver of the guinea pig was shown (1, 2) to contain two enzymes which catalyze the dehydrogenation of testosterone. One is located in the particulate fraction and specifically requires diphosphopyridine nucleotide as hydrogen acceptor; the other, present in the fraction of guinea pig homogenate not sedimented by 24,500 X g for 60 minutes, specifically requires triphosphopyridine nucleotide ...
