BACKGROUND The benefits of intravenous tissue-type plasminogen activator (tPA) in acute ischemic stroke are time dependent, and guidelines recommend an arrival to treatment initiation (door-to-needle) time of ≤60 minutes. METHODS AND RESULTS Data from acute ischemic stroke patients treated with tPA within 3 hours of symptom onset in 1082 hospitals participating in the Get With the Guidelines-...

An annealing time of 30-45 seconds is commonly used in PCR reactions. Increase in annealing time up o 2-3 minutes did not appreciably influence the outcome of the PCR reactions. However, as the polymerase has some reduced activity between 45 and 65 C (interval in which most annealing temperature are chosen), longer annealing times may increase the likelihood of unspecific amplification products...

OBJECTIVE To determine whether people with moderate-to-severe traumatic brain injury (TBI) can adhere to a minimally supervised, community-based, vigorous aerobic exercise program. DESIGN Prospective trial. SETTING Young Men's Christian Association (YMCA) facilities. PARTICIPANTS Community-dwelling volunteers (N=10; 8 men, 2 women; age range, 22-49y) 6 to 15 months after moderate-to-sever...

OBJECTIVES The objectives of this study are to evaluate the impact on voice of both duration and intensity level of 2 hours of continuous oral reading. Voice modifications accompanying changes in intensity level during prolonged reading tasks are analyzed. METHODS Fifty normophonic women undergo two sessions of voice loading in which the required intensity level of voice varied between 60-65 ...

background: cardiovascular disease is the most common cause of death in the world. the aim of this study was to determine the effect of aerobic exercise on serum inflammatory markers in untrained middle-aged women. methods: nineteen healthy female middle-aged were selected by convenience sampling method and were randomly divided into two experimental (n=11) and control (n=8) groups. the exercis...

Background. Cardiac rehabilitation program is aimed at reducing secondary risk factors and improving function in patients undergoing coronary artery bypass grafting run which ultimately may delay or reduce mortality in patients. A major component of cardiac rehabilitation program is exercise. Objective(s). This study is aimed at evaluating the effect of aquatic and dryland training on Perox...

Objective: Diabetes is one of the most common metabolic diseases which can lead to cardiovascular disorders. The purpose of this study was to evaluate the effect of swimming training with cinnamon extract on hematological factors in diabetic rats. Materials and Methods: 60 diabetic rats selected and divided into six group of: (1) control, (2) swimming training, (3) 60mg / kg of cinnamon, (4) 4...

BACKGROUND Moderate-intensity exercise improves blood glucose (BG), but most people fail to achieve the required exercise volume. High-intensity exercise (HIE) protocols vary. Maximal cycle ergometer sprint interval training typically requires only 2.5 minutes of HIE and a total training time commitment (including rest and warm up) of 25 minutes per session. The effect of brief high-intensity e...