Insulin resistance is associated with cardiovascular disease. Impaired insulin receptor substrate (IRS)–mediated signal transduction is a major contributor to insulin resistance. Recently, IRS-1 phosphorylation at serine 307 by stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) has been highlighted as a molecular event that causes insulin resistance. We investigated IRS-1–mediat...

Abstract Study question Could the presence of multicleation at early stages influence further embryo development? Summary answer The multinucleation 2 cell is independent on success, but not 4 stage. What known already multinucleated blastomeres (MNB) in cleaving has been linked to poor development and adverse vitro fertilization (IVF) outcomes, when detecte days 3 culture under inverted micros...

BACKGROUND Polymorphisms at codons 307 and 680 are the most commonly encountered allelic variants of the follicle-stimulating hormone receptor (FSHR) gene. Studies in Caucasians suggest that certain FSHR variants are more common in women with polycystic ovary syndrome (PCOS) than normal women. The objective of this study was to determine the distribution of FSHR gene polymorphisms at codons 307...

Objective: We sought to review our experience with postoperative pancreatic fistulas complicated with bleeding. Patients and Methods: Between January 2001 and September 2015 307 patients underwent pancreatico-duodenoectomies or central pancreatectomies. All cares were reconstructed by pancreaticojejunostomy. Results: Overall 30 day mortality was 3.6% (11 of 307 patients). Seven patients (5 male...