We have evaluated the role of mitochondrial oxidative stress and its association with endoplasmic reticulum (ER) activation in progression obesity-related cardiovascular fibrosis. MitoQ (200 µM) was orally administered for 7 weeks to male Wistar rats that were fed a high-fat diet (HFD, 35% fat) or control (CT, 3.5% fat). Obese animals presented fibrosis accompanied by increased levels extracell...

Milk was collected from 20 primiparous Holstein cows that were distributed into four groups and arranged in a completely randomized design with a 35-day period to determine the effect of feeding fish oil, soybean oil, or their combination on milk production and composition. Experimental diets consisted of: 1) control diet; 2) a diet with 3% (DM basis) added fat from menhaden fish oil; 3) a diet...

PURPOSE We sought to determine the effects of dietary fat on insulin sensitivity and whether changes in insulin sensitivity were explained by changes in abdominal fat distribution or very low-density lipoprotein (VLDL) fatty acid composition. METHODS Overweight/obese adults with normal glucose tolerance consumed a control diet (35 % fat/12 % saturated fat/47 % carbohydrate) for 10 days, follo...

The effects of three isoenergetic diets on metabolic and appetite responses to prolonged intermittent walking were investigated. Eight men undertook three 450-min walks at intensities varying between 25-30 and 50-55% of maximal O2 uptake. In a balanced design, the subjects were given breakfast, snacks, and lunch containing total carbohydrate (CHO), protein (P), and fat (F) in the following amou...

Microsomal triglyceride transfer protein (MTP) is involved in the assembly and secretion of triglyceride-rich lipoproteins from enterocytes and hepatocytes. JTT-130 is a novel intestine-specific MTP inhibitor, which has been shown to be useful in the prevention and treatment of dyslipidemia, obesity, and diabetes. JTT-130 has also been shown to suppress food intake in a dietary fat-dependent ma...

OBJECTIVE To compare the calorie, fat, saturated fat, and sodium content of available children's meal combinations in leading restaurants with national recommendations. DESIGN Cross-sectional. SETTING Children's menu offerings and corresponding nutrition information were collected (May, 2014) from Web sites of the top 10 quick-service (QSR) and top 10 full-service (FSR) restaurant chains th...

Heritability estimates, by year of freshening of daughter, were obtained from daughter-dam and granddaughter-granddam regressions using 61,482 triply matched first lactations of artificially sired Holstein cows obtained from the Northeast Dairy Records Processing Laboratory. After adjusting for herd-year-season effects, residual effects may include additive and other genetic effects of the anim...

A cornerstone of dietary advice for cardiovascular health has been to reduce the intake of total fat to less than 35% of total energy intake, and to reduce saturated fat (SFA) intake to under 11% of total energy intake. However, recent research evidence, as well as media coverage, on the type and amount of dietary fat in obesity and the development and management of type 2 diabetes and cardiova...

background: koobideh kebab (barbequed minced meat) is one of the most popular iranian foods. reduction in the water holding capacity (whc) of meat during thermal processing makes the water and melted fat run out of the meat. the fat content of the final product depends on the proportion of the retained moisture and fat. meanwhile, high temperature and the presence of oxygen and iron in meat may...