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The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-g lutamic acid (1b, TNP-351) and the related compound (1a), was replaced with various N(omega)-acyl-, sulfonyl-, carbamoyl- and aryl-2,omega-diaminoalkanoic acids, and the inhibitory effects of the resulting products (9, 11, 14, 18, 21, 23, 25, 30, 36) on dihydrofolate reductase (DHFR), the growth...
OBJECTIVE To medically and audiologically characterize a population of children diagnosed as having auditory neuropathy (AN). STUDY DESIGN Retrospective medical chart review. SETTING/SUBJECTS We identified 22 patients from a pediatric otology clinic in a tertiary care pediatric hospital setting. RESULTS A genetic factor in AN is suggested by our identification of 3 families with 2 affecte...
Patients with R/R DLBCL are initially treated by cH/Os and require referral for CAR-T. Aspects of the patient’s complex journey not well understood. This study assessed CAR-T recipient care from cH/O perspective. was a retrospective, observational, multicenter recipients in 2019. Charts were abstracted treating capturing treatment patterns outcomes. Data compared months initial diagnosis to (≤1...
BACKGROUND Previous cross-sectional studies have shown that Parkinson's disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients. OBJECTIVE The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls a...
Two comparative serial-slaughter experiments were conducted to determine whole empty body (WEB) composition and accretion rates of Ca and P in 18 to 109 kg BW pigs to provide information for modeling of these nutrients for growth. Both studies were conducted with 5 sets of 5 littermate barrows which were allotted to 5 slaughter groups in each study (Exp. 1: 18, 27, 36, 45, and 54 kg BW; Exp. 2:...
A Complete Bibliography of Publications in ACM Letters on Programming Languages and Systems (LOPLAS)
18]. after [15]. algorithm [29]. algorithmic [22]. alias [2]. analysis [2, 15, 36, 17, 18, 23, 39]. approach [18]. approximation [10]. array [9, 36]. assembly [13]. assignment [12]. assisted [24]. assumption [8].
Nickelconcentrationswere measured by atomic absorption spectrometry in sera.The mean concentration of nickel in sera of 47 healthy adults was 2.6 (SD ± 0.8) ag/liter. Abnormally high mean concentrations (pg/liter) of serum nickel were found in patients with: (a) acute myocardial infarction (13-36 h after onset), mean = 5.2 ± 2.8,N = 33, P <0.001; (b) acute stroke (3772 h afteronset),mean = 4.5,...
PROBLEMA: ¿Qué beneficios tiene potencializar la red de docentes en funciones ejecutivas para preescolar? OBJETIVO: formar a los preescolar sobre importancia las el aprendizaje y su desarrollo con niños edades 3 6 años. MÉTODO: se realizó un estudio descriptivo transversal 80 que participaron capacitándose modalidad online tema “Importancia años, RESULTADOS: rango etario más frecuente fue 18 27...
We tested the hypothesis that cross-reactivity between the outer surface protein A (OspA) of Borellia burgdorferi and human leukocyte function antigen (LFA) type 1 mediates chronic autoimmune sequelae of Lyme disease. T cell response was studied in subjects with Lyme disease presenting with erythema migrans alone (n=36), erythema migrans with neurological disease (n=12), and chronic Lyme diseas...
B. I. Abelev,8 M. M. Aggarwal,30 Z. Ahammed,47 B. D. Anderson,18 D. Arkhipkin,12 G. S. Averichev,11 J. Balewski,22 O. Barannikova,8 L. S. Barnby,2 J. Baudot,16 S. Baumgart,52 D. R. Beavis,3 R. Bellwied,50 F. Benedosso,27 M. J. Betancourt,22 R. R. Betts,8 A. Bhasin,17 A. K. Bhati,30 H. Bichsel,49 J. Bielcik,10 J. Bielcikova,10 B. Biritz,6 L. C. Bland,3 M. Bombara,2 B. E. Bonner,36 M. Botje,27 J....
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