The goal of this research is to develop a generic framework for automatic configuration optimization of big data processing systems. The framework will allow users to specify their performance goals as well as their own metrics. We plan on utilizing system developer provided hints for searching suitable configurations for big data application deployments. Introduction Big data processing system...

Abstract Background Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Despite advances in surgical first-line treatment, all pts relapse. The aim of this study to evaluate benefit metronomic Temozolomide (mTMZ) for recurrent GBM. Material Methods All treated at Veneto Institute Oncology from September 2013 March 2021 were retrospectively reviewed. Major inclusion criter...

Slow wave (or stage N3) sleep has been linked to a variety of cognitive processes. However, the role of stage N3 in the elderly is debated. The link between stage N3 and episodic memory may be weakened or changed in the older adult population, possibly due to several altered mechanisms impacting the cellular structure of the brain. The bases for the age-related dissociation between stage N3 and...

5-Hydroxytryptamine (5-HT) is proarrhythmic in atrial cells from patients in sinus rhythm (SR) via activation of 5-HT(4) receptors, but its effects in atrial cells from patients with atrial fibrillation (AF) are unknown. The whole-cell perforated patch-clamp technique was used to record L-type Ca(2+) current (I(CaL)), action potential duration (APD) and arrhythmic activity at 37 degrees C in en...

Introduction: Intussusception is commonly discussed in the context of children. However in adults, intussusception is an identified diagnosis accounting for 5% of all intussusceptions. A malignant etiology is always suspected in adults; however, rarely as in this case, a benign bowel lesion may be the underlying cause. case report: In this case report, we present an unusual case of a 36-year-ol...

Four of the most active RS CVn stars (V711 Tau, II Peg, Gem, and UX Ari) have been observed for a total of 3Ms with the Extreme Ultraviolet Explorer satellite (EUVE) between 1992 and 2000 January. Flaring and quiescent states of extreme ultraviolet spectra ( 70–740) and light curves ( 75–175) have been analyzed to provide emission measure distributions (EMD) for these systems in the range logTe...

Echolocation is the ability to use sound-echoes to infer spatial information about the environment. Some blind people have developed extraordinary proficiency in echolocation using mouth-clicks. The first step of human biosonar is the transmission (mouth click) and subsequent reception of the resultant sound through the ear. Existing head-related transfer function (HRTF) data bases provide desc...

U ntil recently, physicians tended not to treat hyper-tension in older people. Opinion held that high blood pressure was a useful adaptation to maintain flow in rigid arteriosclerotic arteries and that treatment with antihypertensive drugs would cause postural hypoten-sion and confusion. 1 Well-controlled trials have now demonstrated that treating hypertension in elderly patients reduces the ri...