drug resistance in malaria parasites is extending in the world particularly in chemical synthesized drugs such as 4- aminoquinolines and aminoalcoholes. employing herbal extracts is encouraged by who in the malarious areas. in this study, the effectiveness of ethanolic extract of artemisia aucheri individually and in combination with chloroquine, has been considered against chloroquine - sensit...

Chloroquine and hydroxychloroquine are aminoquinolines used in the treatment of endemic diseases Latin America such as malaria non-endemic with wide prevalence rheumatoid arthritis lupus erythematosus. Described persistent, bioaccumulative, dangerous for aquatic biota, chloroquine considered emerging pollutants intensified by COVID-19 pandemic, occurring low concentrations that not totally remo...

Phosphothreonine (pThr) was found to constitute a new class of chiral phosphoric acid (CPA) catalyst upon insertion into peptides. To demonstrate the potential of these phosphopeptides as asymmetric catalysts, enantioselective transfer hydrogenations of a previously underexplored substrate class for CPA-catalyzed reductions were carried out. pThr-containing peptides lead to the observation of e...

Previous data showing that several chloroquine analogues containing an intramolecular hydrogen-bonding motif were potent against multidrug-resistant P. falciparum led to the exploration of the importance of this motif. A series of 116 compounds containing four different alkyl linkers and various aromatic substitutions with hydrogen bond accepting capability was synthesized. The series showed br...

Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR is a very sensitive technique for free radical detection and characterization. It can be used to investigate very low concentrations of radicals provided that they are stable...