In the anion of the title mol-ecular salt, C(4)H(12)N(2) (2+)·C(11)H(10)O(6) (2-), the two acetate groups form torsion angles of 74.1 (1) and 7.1 (1)° with the central benzene ring, and the cation exhibits a chair conformation. In the crystal, N-H⋯O hydrogen bonds link the components into a two-dimensional supra-molecular network lying parallel to the ab plane. A number of C-H⋯O inter-actions c...

In the title compound, C26H28N2, the piperazine group adopts a chair conformation with the exocyclic N-C bonds in equatorial orientations. The dihedral angle between the geminal benzene rings is 80.46 (12)° and the C=C-C-N torsion angle is 145.9 (2)°. In the crystal, weak C-H⋯π inter-actions link the mol-ecules into [100] chains.

The title crystal structure, C(11)H(18)N(4)O(3), is the first diazo-acetamide in which the diazo-acetyl group is attached to an N atom. The piperazine ring is in a chair form and hence the mol-ecule has an extended conformation. Both ring N atoms are bonded in an essentially planar configuration with the sum of the C-N-C angles being 359.8 (2) and 357.7 (2)°. In the crystal structure, the O ato...

The relationship between the chemical structure and epileptogenic activity of quinolones was investigated. When the quinolones were administered intravenously to mice concomitantly with oral biphenylacetic acid, a major metabolite of the nonsteroidal antiinflammatory drug fenbufen, enoxacin, norfloxacin, ciprofloxacin, and pipemidic acid, which have an unsubstituted piperazine moiety at the 7 p...

Abstract A facile way to introduce CF 3 groups on a large variety of secondary amines has been developed, avoiding expensive and hazardous reagents. The advantage the method could be demonstrated by obtaining crystalline tert ‐butyl 4‐(trifluoromethyl)piperazine‐1‐carboxylate, compound that previously only had obtained as an oil. major problem is extreme sensitivity these compounds towards mois...

in this study oxyuris and ascaris infections alone or in combination were treated with vanapar a combination of pyrvinium pamoate and piperazine administered in two successive daily doses. this resulted in a 100% cure rate of oxyuriasis as well as a substantial reduction in ova count for ascaris, amounting to 97% success rate in achieving ova count reduction. vanapar was highly effective for th...

Structure-cytotoxicity relationships studies have indicated that the C-3 and C-6 disubstituted piperazine-2,5-diones are structurally required for significant cytotoxicity, and the neihumicin-like C-3 and C-6 disubstituted unsymmetrical piperazine derivatives are, in general, more cytotoxic than the corresponding symmetrical piperazine-2,5-diones. Several synthetic analogs including 3,6-di-(2,4...

The asymmetric unit of the title salt, C4H12N2 (2+)·2C6H6NO3S(-), consists of half a piperazindiium dication, located about an inversion centre, and a 4-amino-benzene-sulfonate anion. The piperazine ring adopts a chair conformation. In the crystal, the cations and anions are linked via N-H⋯O and C-H⋯O hydrogen bonds, forming a three-dimensional framework. Within the framework there are C-H⋯π in...

The mol-ecule of the title compound, C(28)H(42)N(6), has site symmetry with the centroid of the piperazine ring located on an inversion center. The piperazine ring adopts a chair conformation. The benzene ring and propyl-piperazine are on opposite sides of the C=N bond, showing an E configuration.