In this report, we investigate the mechanisms that regulate Drosophila histone H1 expression and its association with chromatin in vivo. We show that histone H1 is subject to negative autoregulation and exploit this result to examine the effects of mutations of the main phosphorylation site of histone H1.

Let H1∪P H2 be a Heegaard splitting of a closed 3-manifoldM , i.e., Hi (i = 1, 2) is a handlebody in M such that H1 ∪H2 = M , H1 ∩H2 = ∂H1 = ∂H2 = P . In [13], M.Scharlemann, and A.Thompson had introduced a process for spreading H1 ∪P H2 into a “thinner” presentation. The idea was polished to show that if the original Heegaard splitting is irreducible, then we can spread it into a series (A1 ∪P...

The ganglion cells of primate retina have center-surround receptive fields. A strong candidate for mediating linear surround circuitry is negative feedback from the H1 horizontal cell onto the cone pedicle. We measured the spatial properties of H1 cell receptive fields in the in vitro macaque monkey retina using sinusoidal gratings, spots, and annuli. Spatial tuning curves ranged in shape from ...

Multiple non-allelic subtypes of histone H1 have been detected in higher organisms. These specific variants with distinct structural features may differ in their ability to condense chromatin and hence modify transcriptional activity. Such functional divergence between H1 subtypes has still not been established definitively, but it cannot be excluded that the role of a particular subtype may de...

Nm23 genes, which encode nucleoside diphosphate kinases, have been implicated in suppressing tumor metastasis. The motility of human breast carcinoma cells can be suppressed by transfection with wild-type nm23-H1, but not by transfections with two nm23-H1 mutants, nm23-H1(S12OG) and nm23-H1(P96S). Here we report that nm23-H1 can transfer a phosphate from its catalytic histidine to aspartate or ...

.................................................................................................. 10 POPULÄRVETENSKAPLIG SAMMANFATTNING............................. 12 PAPERS IN THE PRESENT THESIS ....................................................... 15 ABBREVIATIONS ....................................................................................... 16 INTRODUCTION..........................

  Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain.   Material and Methods: Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inf...

ψ and Υ decays may be used to search for light neutral spin-1 or spin-0 bosons associated with a broken extraU(1) symmetry, local or global, acting axially on quarks and leptons, as may be present in supersymmetric theories with a λ H1H2 S superpotential. A light spin-1 gauge boson U may be produced very much as the corresponding Goldstone boson (or light pseudoscalar) a associated with the glo...

1. When isolated perfused lungs from normal and ovalbumin sensitized guinea-pigs were challenged with histamine and 2-methylhistamine (agonists for H1-receptor), a release of thromboxane A2-like substance was observed. The effect of histamine on production of thromboxane A2 (TXA2) in sensitized lungs, was more pronounced than in normal lungs (P less than 0.01). 2. Specific activation of histami...