In recent years there is a tremendous increase of inflammatory cases, leading to the design and development of newer anti-inflammatory agents. The reaction of 2-substituted phenyl-3-chloroacetamido quinazolin-4(3H)-ones with various 5-phenyl-1,3,4-oxadiazole-2-thiol and 5-(pyridine-4-yl)-1,3,4-oxadiazole-2thiol gave N-(4-Oxo-2-substituted phenylquinazolin-3(4H)-yl)-2-[(5-aryl-1,3,4-oxadiazol-2-...

In the present investigation, two novel series of 2-[3-(4-chlorophenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazole and 2-[3-(4-ethylphenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazole were synthesized and tested for their antiinflammatory, analgesic, ulcerogenic and antibacterial actions. A fair number of compounds were found to have very good antiinflammatory activity in car...

The cytochrome P450 eicosanoid 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a powerful endogenous autacoid that has been ascribed an impressive array of physiologic functions including regulation of blood pressure. Because 14,15-EET is chemically and metabolically labile, structurally related surrogates containing epoxide bioisosteres were introduced and have become useful in vitro pha...

The mol-ecule of the title compound, C(7)H(6)N(2)S(3), is almost planar, the dihedral angle between the benzene plane and the 1,3-dithiole-2-thione plane being 2.21 (6)°. In the crystal, mol-ecules are linked by inter-molecular N-H⋯S and N-H⋯N hydrogen bonds into a three-dimensional network. The crystal packing also exhibits weak inter-molecular S⋯S inter-actions [3.5681 (9) Å].

The title compound, C(14)H(8)N(4)O(6), a new 1,2,5-oxadiazole N-oxide derivative, was formed by dimerization of 4-nitro-benz-al-de-hyde oxime. The compound crystallizes with two independent mol-ecules per asymmetric unit. The N-oxide O atom is disordered over two sites in each mol-ecule; site occupancy factors are 0.57/0.43 and 0.5/0.5. The mean planes through the two benzene rings are inclined...

Polycyclic ’cage’ ketones, such as pentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-one (10), pentacyclo[5.4.0.02,6.03,10.05,9]undecane8,11-dione (11), and adamantan-2-one (16) were treated with the nucleophilic dimethoxycarbene (DMC; 1), which was generated thermally from 2,5-dihydro-2,2-dimethoxy-5,5-dimethyl-1,3,4-oxadiazole (4a) in boiling toluene. In this ’one-pot’ procedure, the ahydroxycarboxy...

IN THE TITLE COMPOUND [SYSTEMATIC NAME: 4-(2,3-dibromo-3-phenyl-propano-yl)-3-phenyl-1,2,3-oxadiazol-3-ylium-5-olate], C(17)H(12)Br(2)N(2)O(3), the oxadiazole ring is essentially planar, with a maximum deviation of 0.001 (3) Å. The central oxadiazole ring makes dihedral angles of 73.3 (2) and 29.0 (2)° with the adjacent and remote phenyl rings, respectively. In the crystal, adjacent mol-ecules ...

In the title compound, C(4)H(6)N(2)OS(2), the dihedral angle between the five-membered heterocyclic ring and the plane of the eth-oxy group is 4.9 (2)°. The 1,3,4-thiadiazole-2-thione unit is planar, with an r.m.s. deviation of 0.011 Å from the corresponding squares plane defined by the seven constituent atoms. In the crystal, pairs of N-H⋯S hydrogen bonds link the mol-ecules into inversion dim...