BACKGROUND European and United States Pharmacopoeia compendial procedures for assessing the in vitro emitted dose and aerodynamic size distribution of a dry powder inhaler require that 4.0 L of air at a pressure drop of 4 kPa be drawn through the inhaler. However, the product performance should be investigated using conditions more representative of what is achievable by the patient population....

background menopause is a unique event in a woman’s life which has many symptoms. frequency and severity of these symptoms vary, and they are based on the woman’s epidemiological characteristics. objectives the aim of this study was to determine the prevalence and severity of menopausal symptoms and related factors among women, 40-60 years in kashan, iran. patients and methods in this cross-sec...

BACKGROUND Previous studies exploring the association between 25[OH]D levels and mortality in adults with and without kidney disease utilized 25[OH]D thresholds that have recently been scrutinized by the Institute of Medicine Committee to Review Dietary References Intakes for Vitamin D and Calcium. OBJECTIVE We explored all-cause mortality rates across the spectrum of 25[OH]D levels over an e...

Mental stress induces transient endothelial dysfunction, which is an important finding for subjects at cardiometabolic risk. Thus, we tested whether aerobic exercise prevents this dysfunction among subjects with metabolic syndrome (MetS) and whether an increase in shear rate during exercise plays a role in this phenomenon. Subjects with MetS participated in two protocols. In protocol 1 (n = 16)...

Diagnostic imaging delivering low doses of radiation often accompany human mesenchymal stem cells (MSCs)-based therapies. However, effects of low dose radiation on MSCs are poorly characterized. Here we examine patterns of phosphorylated histone H2AX (γH2AX) and phospho-S1981 ATM (pATM) foci formation in human gingiva-derived MSCs exposed to X-rays in time-course and dose-response experiments. ...

In the present study, a magnetic nanocomposite based on biochar (BC) derived from sugarcane bagasse, nanoscale zerovalent iron (nZVI), and chitosan (CS) was fabricated to investigate its efficacy for removal of two widely used pharmaceutically active compounds (PhACs), namely aspirin (ASA) carbamazepine (CBZ). The synthesized (BC-CS@nZVI) characterized using XRD, FTIR, FESEM-EDX. Response Surfa...

Background: Curcumin and quercetin are the two important flavonoids that being used as food ingredients across globe. They also possess many pharmacological activities such anti-inflammatory, anticancer antidiabetic activity. The combination of both these phytoconstituents is available in market. However, there lack any suitable analytical method reported for their simultaneous estimation well ...

The primary objective of the current study was to determine the effect of moderate normobaric hypoxia exposure during constant load cycling on post-exercise energy metabolism recorded in normoxia. Indirect calorimetry was used to examine whole body substrate oxidation before, during, 40-60 min post, and 22 h after performing 60 min of cycling exercise at two different fractions of inspired oxyg...

A multilevel factorial design of 23 with 12 experiments was developed for the preparation cellulose nanocrystals (CNC) from Agave tequilana Weber var. Azul bagasse, an agro-industrial waste tequila production. The studied parameters were acid type (H2SO4 and HCl), concentration (60 65 wt% H2SO4, 2 8N HCl) temperature (40 60 °C 50 90 hydrolysis time (40, 55 70 min H2SO4; 30, 115 200 HCl). obtain...