Health services in many developed countries are experiencing an urgent need for innovation in response to an ageing population and the growing prevalence of chronic and degenerative diseases.Many urge reform of what are now perceived as inadequate and outdated services that have traditionally focused on a medical model predicated on access, continuity, integration and comprehensive care. Differ...

This study evaluated the effects of inoculation with the arbuscular mycorrhizal fungi Glomus mosseae, Glomus intraradices A4 and Glomus intraradices B1 and two phosphorus levels (10 and 40 mg kg-1) on root colonization, plant growth, nutrient uptake and essential oil content in Mentha piperita L. The experiment was carried out in a greenhouse, in 4x2 factorial arrangement, in completely randomi...

Invariant NK T cells express certain NK cell receptors and an invariant TCR chain specific for the MHC class I-like CD1d protein. These invariant NK T cells can regulate diverse immune responses in mice, including antitumor responses, through mechanisms including rapid production of IL-4 and IFN, but their physiological functions remain uncertain. Invariant NK T cells were markedly decreased in...

Zircons are crucial to understanding the first 500 Myr of crustal evolution of Earth. Very few zircons of this age (>4050 Ma) have been found other than from a ~300 km diameter domain of the Yilgarn Craton, Western Australia. Here we report SIMS U-Pb and O isotope ratios and trace element analyses for two ~4100 Ma detrital zircons from a Paleozoic quartzite at the Longquan area of the Cathaysia...

Following initial infection, herpesviruses retreat into a permanent latent state with periodic reactivation resulting in an enhanced likelihood of transmission and clinical disease. The nucleoside analogue acyclovir reduces clinical symptoms of the three human alpha herpesviruses, HSV-1, HSV-2, and VZV. Long-term administration of acyclovir (ACV) can reduce the frequency and severity of reactiv...

We report the results of a phase 2 trial using lenalidomide plus dexamethasone (Rev/ Dex) as initial therapy for myeloma. Thirtyfour patients were enrolled. Lenalidomide was given orally 25 mg daily on days 1 to 21 of a 28-day cycle. Dexamethasone was given orally 40 mg daily on days 1 to 4, 9 to 12, and 17 to 20 of each cycle. Objective response was defined as a decrease in serum monoclonal pr...

Tanz RD, Marcus SM (1966) Influence of endogenous cardiac catecholamine depletion on the force and rate of isolated heart preparations and their response to ouabain. J Pharamcol Exp Ther 151: 38-45 Thorpe WP (1973) Some effects of caffeine and quinidine on sarcoplasmic reticulum of skeletal and cardiac muscle. Can J Physiol Pharmacol 51: 499-503 Thyrum PT (1974) Inotropic stimuli and systolic t...

Pattern formation at the solid-liquid interface of a growing crystal was studied in directional solidification using a perturbation technique. We analyzed both experimentally and numerically the stability range and dynamical selection of cellular arrays of ‘‘doublets’’ with asymmetric tip shapes, separated by alternate deep and shallow grooves. Applying an initial periodic perturbation of arbit...

Although phylogenetic approaches are useful for providing insights into the processes underlying biodiversity patterns, the studies of microbial phylogenetic relatedness are rare, especially for elevational gradients. Using high-throughput pyrosequencing, we examined the biodiversity patterns for biofilm bacterial communities that were scraped from stream stones along an elevational gradient fr...

OBJECTIVE To determine whether there was a relationship between coded diseases at the time of hospital discharge, a pattern of ordering investigations, and hospital readmission in a major teaching hospital. DESIGN Systematic review of data relating to emergency medical patients admitted to St James' Hospital Dublin between 1 January and 31 December 2002. DATA SOURCES AND METHODS Data on dis...