The tumor suppressor molecule p53 features a regulatory domain at the C terminus that recognizes damaged DNA. Since damaged DNA might be involved in activating anti-DNA autoantibodies, we tested whether autoimmunity to the C terminus of p53 might mark murine systemic lupus erythematosus (SLE). We now report that MRL / MpJ-Fas(lpr) mice, which spontaneously develop SLE, produce antibodies both t...

We report results from our monitoring of the BL Lac object Mrk 421 in the near-IR J band. The observations, aimed at studying the intraday variability (IDV) of the object, were carried out systematically over an extended (and near-continuous) period of eight nights from the 1.2m Mount Abu Infrared Telescope, India. There are limited studies for Mrk 421 in the J band for such an extended period....

Introduction. Conventional gradient calibration procedures do not exclude significant bias in the diffusion-weighted (DW) signal during MR experiments. The error, arising from imperfections in the DW gradients, varies among the different gradient directions and exhibits different extent of offsets. We propose a calibration method for DW imaging using a homogeneous water phantom, presuming that ...

BACKGROUND To evaluate diffusion-weighted MR neurography (DW-MRN) for visualizing the brachial plexus and for the assessment of brachial plexopathy. METHODS 40 oncological patients with symptoms of brachial plexopathy underwent 1.5 T MRI using conventional MR sequences and unidirectional DW-MRN. The images were independently reviewed by two radiologists. Anatomic visualization of the brachial...

Several approaches have been proposed to model different aspects of a Data Warehouse (DW) during recent years, such as the modeling of a DW at the conceptual and logical level, the design of the ETL (Extraction, Transformation, Loading) processes, the derivation of the DW models from the enterprise data models, and customization of a DW schema. At the end of the design, a DW has to be deployed ...

Magnetic resonance (MR) imaging of the scrotum represents an important supplemental diagnostic tool in the evaluation of scrotal diseases. Diffusion-weighted (DW) MR imaging is a developing technique, proved to improve tissue characterization. We evaluated the feasibility and diagnostic performance of DW MR imaging in the detection and characterization of scrotal lesions. We retrospectively eva...

The purpose of the study was to determine the concentration of bisphenol A (BPA), 4-tert-octylphenol (OP), and 4-nonylphenol (NP), in human hair, the fur of Baltic grey seals and the feathers of herring gulls. Hair was collected from 42 volunteers, while grey seal fur (n = 17) came from the seal centre in Hel (Marine Station of Institute of Oceanography, University of Gdansk) and gull covert fe...

BACKGROUND AND PURPOSE On diffusion-weighted (DW) images, primary hematomas are initially mainly hyperintense, and then hypointense during the first few days after stroke onset. As in other brain disorders, variations in the T2 relaxation time of the hematoma influence the DW imaging signal intensity. Our aim was to evaluate the contribution of the T2 signal intensity and apparent diffusion coe...

Studies on how the body senses the need to correct extracellular and intracellular volumes and ionic concentration changes is relatively scanty. The present studies were designed to determine the effect of oral distilled water (DW) and saline loads, gargling with DW and DW preload on thirst perception (TP) and drinking in euhydrate and dehydrated subjects. The subjects were healthy male volunte...

BACKGROUND AND PURPOSE Identifying tissue at risk for infarction is an important goal of stroke imaging. This study was performed to determine whether pixel-based apparent diffusion coefficient (ADC) and signal intensity ratio are helpful diffusion-weighted (DW) imaging metrics to predict tissue at risk for infarction. METHODS Twelve patients presenting with acute hemispheric strokes underwen...