A systematic study of the modification of papain (its thiol group protected as a disulphide with mercaptoethanol) by N-bromosuccinimide, showed that 2 molar equiv. modified tryptophan-69 and 4 molar equiv. modified tryptophan-69 and -177. The Michaelis parameters for the catalysed hydrolysis of N-benzyloxycarbonylglycine p-nitrophenyl ester by these modified enzymes were determined. The enzymic...

This memo considers some dynamic range issues resulting from limitations in the polarimetric calibration solutions used in typical observations. Whereas we focus on “traditional” radio interferometric telescopes such as the VLA, ATCA or ALMA, the analysis approach can be used for other interferometer arrays. The memo is mostly concerned with the principles: rather than addressing real data, thi...

In this paper, we generalize the classical Freidlin-Wentzell’s theorem for random perturbations of Hamiltonian systems. (Probability Theory and Related Fields 128 (2004) 441–466), M.Freidlin M.Weber generalized original result in sense that coefficient noise term is no longer identity matrix but a state-dependent taking drift into consideration. We by adding converges uniformly to 0 on any comp...

BACKGROUND Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on pain reduction and on improving the quality of life of the patient. Particularly, patients w...

UNLABELLED Tumor vessels abundantly express receptors for vascular endothelial growth factor (VEGF), despite treatment with conventional or antiangiogenic drugs. We wished to determine whether the high levels of VEGF receptor (VEGFR) within the tumor vasculature could be leveraged for intracellular delivery of therapeutically significant doses of scVEGF/(177)Lu, a novel radiopharmaceutical base...

18.1 Context of the ECM ...................................................... 461 18.1.1 ECM – What’s in a Name? ............................................. 462 18.1.2 Old and New ECMs ........................................................ 462 18.1.3 Biophysical Considerations ............................................. 462 18.1.4 Jelly Bombs ................................................