EDWARD J. PULIDO,1 BRIAN D. SHAMES,1 DAVID A. FULLERTON,2 BRETT C. SHERIDAN,1 CRAIG H. SELZMAN,1 FABIA GAMBONI-ROBERTSON,1 DENIS D. BENSARD,3 AND ROBERT C. MCINTYRE, JR1 1Department of Surgery, University of Colorado Health Sciences Center and The Veterans Affairs Hospital, Denver 80262; 3Department of Pediatric Surgery, The Children’s Hospital, Denver, Colorado 80218; and 2Department of Surger...

Jaggar, Jonathan H., Valerie A. Porter, W. Jonathan Lederer, and Mark T. Nelson. Calcium sparks in smooth muscle. Am. J. Physiol. Cell Physiol. 278: C235–C256, 2000.—Local intracellular Ca21 transients, termed Ca21 sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca21 release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca21 sparks are activate...

Rys-Sikora, Krystyna E., Raymond L. Konger, John W. Schoggins, Rama Malaviya, and Alice P. Pentland. Coordinate expression of secretory phospholipase A2 and cyclooxygenase-2 in activated human keratinocytes. Am J Physiol Cell Physiol 278: C822–C833, 2000.—PGE2 levels are altered in human epidermis after in vivo wounding; however, mechanisms modulating PGE2 production in activated keratinocytes ...

Shi, Hong, Hui-Zhen Wang, and Zhiguo Wang. Extracellular Ba21 blocks the cardiac transient outward K1 current. Am. J. Physiol. Heart Circ. Physiol. 278: H295–H299, 2000.—Ba21 is widely used as a tool in patch-clamp studies because of its ability to block a variety of K1 channels and to pass Ca21 channels. Its potential ability to block the cardiac transient outward K1 current (Ito) has not been...

OLUGBENGA A. ADEBANJO,1 GOPA BISWAS,2 BALJIT S. MOONGA,1 HINDUPUR K. ANANDATHEERTHAVARADA,2 LI SUN,1 PETER J. R. BEVIS,1 BALI R. SODAM,1 F. ANTHONY LAI,3 NARAYAN G. AVADHANI,2 AND MONE ZAIDI1 1Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, and Bronx Veterans Affairs Geriatric Research Education and Clinical Center, New York 10029; 2School of Veterinary Medicine, Unive...

Ali, Shujath M., Victoria Y. Wong, Kristine Kikly, Todd A. Fredrickson, Paul M. Keller, Walter E. DeWolf, Jr., Dennis Lee, and David P. Brooks. Apoptosis in polycystic kidney disease: involvement of caspases. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R763– R769, 2000.—Polycystic kidney disease (PKD) is characterized by the development of large renal cysts and progressive loss o...

Matsumura, Kiyoshi, Isao Abe, Takuya Tsuchihashi, and Masatoshi Fujishima. Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits. Am J Physiol Regulatory Integrative Comp Physiol 278: R1314–R1320, 2000.—We determined the cardiovascular and neurohormonal responses to intracerebroventricular injection of leptin in conscious rabbits. Intracerebroventricular i...

Burckhardt, Gerhard, and Natascha A. Wolff. Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 278: F853–F866, 2000.—Here we review the structural and functional properties of organic anion transporters (OAT1, OAT2, OAT3) and organic cation transporters (OCTN1, OCTN2, OCT1, OCT2, OCT3), some of which are involved in renal proximal tubular organic anion and cati...

Peri, Irena, Hanna Mamrud-Brains, Sergey Rodin, Valery Krizhanovsky, Yechiel Shai, Shlomo Nir, and Michael Naim. Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction. Am. J. Physiol. Cell Physiol. 278: C17–C25, 2000.— Some amphipathic bitter tastants and non-sugar sweeteners are direct activators of G proteins and stimulate transduction p...