Acinetobacter baumannii is the most common species to have developed resistance to antibiotics. Due to increasing levels of drug resistance, the available therapeutic options are insufficient in A. baumannii infections. This study investigated the efficacy of doripenem monotherapy versus doripenem combination therapy with sulbactam, amikacin, colistin and tigecycline in experimental sepsis. A c...

Information on the effects of injury on neovascularization in the immature brain is limited. We investigated the effects of ischemia on cerebral cortex neovascularization after the exposure of fetuses to 30 minutes of cerebral ischemia followed by 48 hours of reperfusion (I/R-48), 30 minutes of cerebral ischemia followed by 72 hours of reperfusion (I/R-72), or sham control treatment (Non-I/R). ...

Different methods for spinal cord ischemia (SCI) prevention with sac perfusion are reported before the completion of endovascular thoracoabdominal aortic aneurysm repair; however, today there no described techniques reperfusion in case SCI occurring after complete exclusion (48-72 hours). The “safe-line” technique allows a simple and fast (within 1 hour from symptom onset) up to 72 hours comple...

BACKGROUND XaraColl, a collagen-based implant that delivers bupivacaine to sites of surgical trauma, has been shown to reduce postoperative pain and use of opioid analgesia in patients undergoing open surgery. We therefore designed and conducted a preliminary feasibility study to investigate its application and ease of use for laparoscopic surgery. METHODS We implanted four XaraColl implants ...

OBJECTIVES This study compared 24-, 48-, 72-, and 96-hour buprenorphine dosing regimens in opioid-dependent outpatients. METHODS Fourteen subjects received buprenorphine in a double-blind, placebo-controlled crossover trial. Daily sublingual maintenance doses were 4 mg/70 kg (n = 5) and 8 mg/70 kg (n = 9). After a stabilization period of maintenance administration, subjects received, in a ran...

OBJECTIVE To determine whether surgical detorsion is effective in preventing surgical resection in a rat model of ovarian torsion. METHODS This study was performed between July 2002 and May 2003 in the Department of Obstetrics and Gynecology of Gaziantep University Hospital, Gaziantep, Turkey. Fifty adult female rats were randomized into 10 groups. The right ovaries in the study groups were m...

arginine vasopressin as a supplementary vasopressor in septic shock restores vascular tone and mean arterial pressure, meanwhile decreases dose and exposure time to catecholamines. the objective of this study was to evaluate the effect of vasopressin on lactate and lactate clearance as markers of tissue perfusion during septic shock. in this prospective, randomized, controlled trial, 30 patient...

Objective: Intense muscle contractions are associated with oxidative stress and immune system deficiency, especially in the presence of obesity. This study aimed to determine the effect of whey protein supplementation following eccentric resistance contractions on some determinants of oxidative stress in non-athletic obese students. Materials and Methods: In this double blinded randomized clin...