Pancreatic carcinoma is the fourth leading cause of death worldwide [21]. Despite certain advances in diagnosis, surgical procedures and chemotherapy, the prognosis of pancreatic cancer patients remains dismal [27]. Resection of the tumor at an early stage of the disease is the only curative treatment option. Unfortunately, as pancreatic cancer lacks early symptoms, less than 25% of patients un...

We investigated systematically the effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation in synthetic duplex DNA. We found that the replacement of 5-methylcytosine at a CpG site with a 5-hydroxymethylcytosine, 5-formylcytosine, 5-carboxylcytosine or 5-hydroxymethyluracil resulted in altered methylation of cytosine at both the opposite a...

To the Editor: Male breast cancer is a rare disease, accounting for less than 1% of total malignant diseases and less than 1% of all breast cancer cases (1). Inspired by the Ruddy and Winer’s article published in Annals of Oncology (2), we analyzed our group of patients treated at the Oncology Institute of Vojvodina from 2006 to 2010. We analyzed the medical records of 44 patients managed at ou...

Background/Introduction Anthracycline-related cardiac dysfunction is a recognised consequence of cancer therapies. Here we assess resting and skeletal muscle energic status as an early mechanistic pathway myocyte derangement explore molecular targets metabolism, protein synthesis/degradation mitochondrial biogenesis signalling. Methods We conducted prospective, mechanistic, ob...

BACKGROUND & OBJECTIVES Nausea and vomiting remain the most distressing side effects of cancer chemotherapy. The present study aimed to study the efficacy and tolerability of ondansetron versus (vs) metoclopramide in different dose related grades of cisplatin induced acute emesis. METHODS A total of 137 patients were enrolled and 80 completed the study. Cisplatin 60 mg/m2 was given intravenou...

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Nucleotide variants, especially those related to epigenetic functions, provide critical regulatory information beyond simple genomic sequence, and they define cell status in higher organisms. 5-Methylcytosine, which is found in DNA, was until recently the only nucleotide variant studied in terms of epigenetics in eukaryotes. However, 5-methylcytosine has turned out to be just one component of a...

Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). Despite their importance as epigenetic markers and as central players in cellular processes, it is not well understood how these modifications influence physical properties of DNA and chromatin. Here we report a co...