INTRODUCTION In two solanezumab trials for mild-to-moderate Alzheimer's disease (AD) dementia, 27% of patients had biomarker confirmation of amyloid status. Of these, approximately 25% of mild patients and approximately 10% of moderate patients were amyloid negative and, as a group, did not exhibit clinical progression typical of AD. This post-hoc analysis describes a statistical surrogate for ...

Extracts of the body walls of Ascaris lumbricoides were reported by Green (2) to contain one substance capable of inhibiting chymotrypsin cy and another substance capable of inhibiting trypsin. Peanasky and Laskowski (3) separated these inhibitors by means of continuous paper curtain electrophoresis and crystallized the chymotrypsin inhibitor. The crystalline preparation, however, was heterogen...

OBJECTIVE To check if signs of rectangularisation of the survival curve appeared during recent decades in Switzerland--that is, if life expectancy is approaching a maximum with a clustering of age at death around an average value (the so called "compression of mortality"). METHODS Descriptive analysis of age of death and its trends over 26 years, as characterised by the modal value, median, a...

BACKGROUND AND OBJECTIVES Heart rate (HR) is frequently used by clinicians in the hospital to assess a patient's severity of illness and make treatment decisions. We sought to develop percentiles that characterize the relationship of expected HR by age and body temperature in hospitalized children and to compare these percentiles with published references in both primary care and emergency depa...

MODELING RETIREE HEALTH COSTS: This Issue Brief examines the uncertainty of health care expenses in retirement by using a Monte Carlo simulation model to estimate the amount of savings needed to cover health insurance premiums and out-of-pocket health care expenses. This type of simulation is able to account for the uncertainty related to individual mortality and rates of return, and computes t...