Manganese peroxidase (MnP) from Phanerochaete chrysosporium undergoes a pH-dependent conformational change evidenced by changes in the electronic absorption spectrum. This high- to low-spin alkaline transition occurs at approximately 2 pH units lower in an F190I mutant MnP when compared to the wild-type enzyme. Herein, we provide evidence that these spectral changes are attributable to the form...

PURPOSE Proton radiation, when compared with photon radiation, allows delivery of increased radiation dose to the tumor while decreasing dose to adjacent critical structures. Given the recent expansion of proton facilities in the United States, the long-term sequelae of proton therapy should be carefully assessed. The objective of this study was to compare the incidence of second cancers in pat...

Este artículo reseña: Fernando H. LLANO ALONSO (dir.), Joaquín GARRIDO MARTÍN y Ramón VALDIVIA JIMÉNEZ (coords.), Inteligencia artificial Filosofía del derecho . Ediciones Laborum, Murcia, 2022, 558 pp.

Background: Mediterranean diet is considered to be a healthy and convenient model due both its physical mental benefits. Therefore, the aim of present research detail pattern, academic performance self-concept, anxiety activity practice in university students, as well establish relationships between variables. Methods: A descriptive cross-sectional study was carried out with sample 558 undergra...

The physiologic activator of factor X consists of a complex of factor IXa, factor VIIIa, Ca(2+) and a suitable phospholipid surface. In one study, helix 330 (162 in chymotrypsin) of the protease domain of factor IXa was implicated in binding to factor VIIIa. In another study, residues 558-565 of the A2 subunit of factor VIIIa were implicated in binding to factor IXa. We now provide data, which ...