Thromboangiitis obliterans (TAO) is an unusual tobacco-associated vasculopathy that is a nonatherosclerotic inflammatory disorder of unknown etiology that affects small and mediumsized vessels of the extremities. The single guanosine nucleotide deletion/insertion polymorphism (4G/5G) at -675 bp in promoter region of the PAI-1 gene is the major genetic determinant of PAI-1 expression. Plasma PAI...

In this paper, we exploit the 3D-beamforming features of multiantenna equipment employed in fifth generation (5G) networks, operating in the millimeter wave (mmW) band, for accurate positioning and tracking of users. We consider sequential estimation of users’ positions, and propose a twostage extended Kalman filter (EKF) that is based on reference signal received power (RSRP) measurements. In ...

Radiation-induced liver toxicity is a major limitation to the use of radiation in the treatment of intrahepatic cancers. The purpose of this study was to evaluate the potential radioprotective effect of a smallmolecule tumor necrosis factor alpha (TNF-) inhibitor, UTL-5g, against radiation-induced acute liver injury. Mice were pre-treated by i.p. injection with UTL-5g and control vehicle one h...

As the rollout of 4G mobile communication networks takes place, representatives of industry and academia have started to look into the technological developments toward the next generation (5G). Several research projects involving key international mobile network operators, infrastructure manufacturers, and academic institutions, have been launched recently to set the technological foundations ...

Internet has shown itself to be a catalyst for economic growth and social equity but its potency is thwarted by the fact that the Internet is off limits for the vast majority of human beings. Mobile phones—the fastest growing technology in the world that now reaches around 80% of humanity—can enable universal Internet access if it can resolve coverage problems that have historically plagued pre...

This article provides an overview on objectives and first results of the Horizon 2020 project 5G NOvel Radio Multiservice adaptive network Architecture (5GNORMA). With 5G NORMA, leading players in the mobile ecosystem aim to underpin Europe’s leadership position in 5G. The key objective of 5G NORMA is to develop a conceptually novel, adaptive and future-proof 5G mobile network architecture. Thi...

OBJECTIVE The development of osteoporosis is associated with several risk factors, such as genetic structures that affect bone turnover and bone mass. The impact of genetic structures on osteoporosis is not known. Plasminogen activator inhibitor type-1 regulates the bone matrix and bone balance. This study assessed the correlation between plasminogen activator inhibitor type-1 gene 4G/5G polymo...

OBJECTIVE To assess whether the -675 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is associated with obesity and insulin resistance in Mexican children. METHODS A cross-sectional study was performed in 174 children, 89 with normal-weight and 85 with obesity, aged from 6 to 13 years. All children were from state of Guerrero, and recruited from three primary schools in the c...

This paper highlights use cases, emerging machine type communication (MTC) technologies, ongoing research activities, and existing research challenges in 5G networks. 5G networks are faced with the following challenges: (i) handling large amounts of data, (ii) coping with different types of data traffic, i.e., human-type, machine-type, and combined-type (iii) connecting billions of machines, an...

MmWave communications are expected to play a major role in the Fifth generation of mobile networks. They offer a potential multi-gigabit throughput and an ultra-low radio latency, but at the same time suffer from high isotropic pathloss, and a coverage area much smaller than the one of LTE macrocells. In order to address these issues, highly directional beamforming and a very high-density deplo...