some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. stiripentol (stp) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. it has poor aqueous solubilityand its solubility has to be enhanced accordingly. polyethyleneglycol 6000 (peg-6000) iscommonly utilized as a hydrophilic...

The purpose of the study was to increase the dissolution and bioavailability of BCS class II drug, paliperidone by amorphization. The technique that was evaluated for preparing amorphous paliperidone (PAL) was Hot Melt Extrusion (HME). In case of hot melt extrusion process, copovidone was used essentially as a hydrophilic polymer with plasticizers like PEG (6000 and 20000), stearic acid and cet...

BACKGROUND Mycophenolic acid (MPA) is an immunosuppressant for which therapeutic drug monitoring (TDM) is performed for optimal prophylaxis and avoidance of toxicity in transplant patients. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is ideally suited for TDM of MPA. There have been several method comparisons of the Roche Total MPA assay, but none have been performed with respect ...

Simple COMA is a method for sharing address spaces among different nodes of a distributed memory computer. This method provides high performance without the complex and costly changes required by other shared memory organizations. It also retains the positive attributes of a distributed memory multicomputer, such as scalability and high availability. This paper explains the Simple COMA shared m...

Abstract Purpose To prepare stable sustained-release (SR) pellets, containing high ibuprofen (IBU) loading, by hot-melt extrusion (HME) technique using polyethylene glycol 6000 (PEG 6000) and glyceryl monostearate (GMS). Methods HME pellets (60% w/w IBU) were prepared PEG 6000, GMS, mixture of both polymers (1:1). Stability studies performed under stress conditions (40 °C relative humidity “RH”...

BACKGROUND An elevated white blood cell (WBC) count is a characteristic finding in pneumococcal pneumonia. Very low WBC counts, occurring in some cases, are often associated with overwhelming pneumonia and have been attributed to alcohol-induced suppression of bone marrow. However, a systematic study of neutropenia, leukocytosis, alcohol ingestion, and cirrhosis in pneumococcal pneumonia has no...

Supercapacitors, as one of alternative energy devices, have been characterized by the rapid rate of charging and discharging, and high power density. But they are now challenged to achieve their potential energy density that is related to specific capacitance. Thus it is extremely important to make such materials with high specific capacitances. In this report, we have gained homogenous Ni(OH)2...

Copper is a very versatile transition metal that has been used as a building material by human civilizations for over 6000 years. Copper is also an essential element, responsible for important biological processes. The title of this Thematic Series published in the Beilstein Journal of Organic Chemistry is “Copper catalysis in organic synthesis”. A web of scienceTM topic search of “copper-catal...

We have raised a rabbit antiserum to a synthetic peptide corresponding to the C terminus (residues 400-416) of the Rh30A polypeptide. The rabbit antiserum reacted with the Rh30B (D30) polypeptide in addition to the Rh30A (C/c and/or E/e) polypeptide(s), indicating that these proteins share homology at their C termini. The antiserum did not react with erythrocyte membranes from an individual wit...